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Chlorine in PDB 2wsa: Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Enzymatic activity of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
All present enzymatic activity of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646):
2.3.1.97;
2.3.1.97;
Protein crystallography data
The structure of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa
was solved by
D.A.Robinson,
S.Brand,
A.H.Fairlamb,
M.A.J.Ferguson,
J.A.Frearson,
P.G.Wyatt,
Structural Genomics Consortium(Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 47.510, 90.317, 52.972, 90.00, 112.27, 90.00 |
| R / Rfree (%) | 17.6 / 21.296 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
(pdb code 2wsa). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646), PDB code: 2wsa:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 2wsa
Go back to
Chlorine Binding Sites List in 2wsa
Chlorine binding site 1 out
of 2 in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646) within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 2wsa
Go back to
Chlorine Binding Sites List in 2wsa
Chlorine binding site 2 out
of 2 in the Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Leishmania Major N- Myristoyltransferase (Nmt) with Bound Myristoyl-Coa and A Pyrazole Sulphonamide Ligand (DDD85646) within 5.0Å range:
|
Reference:
J.A.Frearson,
S.Brand,
L.A.T.Cleghorn,
S.Mcelroy,
O.Smid,
L.Stojanovski,
L.Torrie,
D.A.Robinson,
I.Hallyburton,
M.L.Guther,
H.P.Price,
C.P.Mpamhanga,
J.A.Brannigan,
M.Hodgkinson,
O.Raimi,
D.M.F.Van Aalten,
R.Brenk,
I.H.Gilbert,
K.D.Read,
A.H.Fairlamb,
M.A.J.Ferguson,
D.F.Smith,
P.G.Wyatt.
N-Myristoyltransferase Inhibitors As New Leads to Treat Sleeping Sickness. Nature V. 464 728 2010.
ISSN: ISSN 0028-0836
PubMed: 20360736
DOI: 10.1038/NATURE08893
Page generated: Sat Jul 20 13:16:59 2024
ISSN: ISSN 0028-0836
PubMed: 20360736
DOI: 10.1038/NATURE08893
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