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Chlorine in PDB 2wxf: The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39.
Enzymatic activity of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39.
All present enzymatic activity of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39.:
2.7.1.153;
2.7.1.153;
Protein crystallography data
The structure of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39., PDB code: 2wxf
was solved by
A.Berndt,
S.Miller,
O.Williams,
D.D.Lee,
B.T.Houseman,
J.I.Pacold,
F.Gorrec,
W.-C.Hon,
Y.Liu,
C.Rommel,
P.Gaillard,
T.Ruckle,
M.K.Schwarz,
K.M.Shokat,
J.P.Shaw,
R.L.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.95 / 1.90 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 142.420, 65.010, 116.690, 90.00, 103.53, 90.00 |
| R / Rfree (%) | 21 / 24 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39.
(pdb code 2wxf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39., PDB code: 2wxf:
In total only one binding site of Chlorine was determined in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39., PDB code: 2wxf:
Chlorine binding site 1 out of 1 in 2wxf
Go back to
Chlorine Binding Sites List in 2wxf
Chlorine binding site 1 out
of 1 in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with Pik-39. within 5.0Å range:
|
Reference:
A.Berndt,
S.Miller,
O.Williams,
D.D.Lee,
B.T.Houseman,
J.I.Pacold,
F.Gorrec,
W.-C.Hon,
Y.Liu,
C.Rommel,
P.Gaillard,
T.Ruckle,
M.K.Schwarz,
K.M.Shokat,
J.P.Shaw,
R.L.Williams.
The P110D Structure: Mechanisms For Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol. V. 6 117 2010.
ISSN: ISSN 1552-4450
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
Page generated: Sat Jul 20 13:23:09 2024
ISSN: ISSN 1552-4450
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
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