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Chlorine in PDB 2wzx: Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02

Enzymatic activity of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02

All present enzymatic activity of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02:
3.5.2.6;

Protein crystallography data

The structure of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02, PDB code: 2wzx was solved by P.M.D.Fitzgerald, N.Sharma, J.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.62 / 1.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 44.759, 72.135, 105.933, 90.00, 90.00, 90.00
R / Rfree (%) 18.213 / 19.799

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02 (pdb code 2wzx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02, PDB code: 2wzx:

Chlorine binding site 1 out of 1 in 2wzx

Go back to Chlorine Binding Sites List in 2wzx
Chlorine binding site 1 out of 1 in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-02 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1000

b:21.3
occ:1.00
OE1 A:GLN146 2.6 10.9 0.5
O A:HOH2187 3.0 31.5 1.0
O A:HOH2195 3.1 12.1 1.0
N A:PHE147 3.3 10.5 1.0
CA A:GLN146 3.6 10.2 0.5
CB A:ASN179 3.6 8.1 1.0
ND2 A:ASN179 3.6 12.5 1.0
CB A:GLN146 3.6 10.6 0.5
O A:HOH2054 3.6 39.5 1.0
CA A:GLN146 3.6 9.8 0.5
CD2 A:PHE147 3.7 10.8 1.0
CD A:GLN146 3.8 10.3 0.5
CB A:GLN146 3.8 9.8 0.5
C A:GLN146 4.0 10.1 0.5
C A:GLN146 4.0 9.8 0.5
CG A:GLN146 4.0 11.9 0.5
CG A:ASN179 4.1 10.8 1.0
CE2 A:TYR249 4.2 8.8 1.0
CB A:PHE147 4.2 11.0 1.0
CA A:PHE147 4.3 10.9 1.0
CG A:GLN146 4.4 10.0 0.5
CG A:PHE147 4.4 10.5 1.0
CD A:PRO180 4.5 7.8 1.0
O A:PRO243 4.6 8.1 1.0
CE2 A:PHE147 4.7 9.7 1.0
C22 A:ZX0600 4.7 17.3 1.0
O A:LEU145 4.8 9.8 1.0
C21 A:ZX0600 4.8 19.2 1.0
OH A:TYR249 4.8 9.5 1.0
NE2 A:GLN146 4.9 11.6 0.5
O A:PHE147 4.9 11.7 1.0
CD A:GLN146 4.9 14.4 0.5
N A:GLN146 4.9 9.7 0.5
N A:GLN146 4.9 9.5 0.5
CZ A:TYR249 4.9 9.5 1.0
CA A:ASN179 4.9 8.2 1.0
CD2 A:TYR249 5.0 9.8 1.0

Reference:

T.A.Blizzard, H.Chen, S.Kim, J.Wu, K.Young, Y.Park, A.Ogawa, S.Raghoobar, R.E.Painter, N.Hairston, S.H.Lee, A.Misura, T.Felcetto, P.M.D.Fitzgerald, N.Sharma, J.Lu, S.Ha, E.Hickey, J.Hermes, M.L.Hammond. Side Chain Sar of Bicyclic Beta-Lactamase Inhibitors (Blis). 1. Discovery of A Class C Bli For Combination with Imipinem. Bioorg.Med.Chem.Lett. V. 20 918 2010.
ISSN: ISSN 0960-894X
PubMed: 20044254
DOI: 10.1016/J.BMCL.2009.12.069
Page generated: Sat Dec 12 09:24:38 2020

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