Chlorine in PDB 2wzz: Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03

All present enzymatic activity of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03:
3.5.2.6;

The structure of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03, PDB code: 2wzz was solved by P.M.D.Fitzgerald, N.Sharma, J.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.93 / 1.57
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.791, 72.575, 106.271, 90.00, 90.00, 90.00
R / Rfree (%)	18.058 / 19.659

The binding sites of Chlorine atom in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03 (pdb code 2wzz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03, PDB code: 2wzz:

Chlorine binding site 1 out of 1 in the Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Amp-C Beta-Lactamase (Pseudomonas Aeruginosa)in Complex with Compound M-03 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1000 b:19.6 occ:1.00 O A:HOH2187 3.0 13.1 1.0 O A:HOH2181 3.1 28.6 1.0 N A:PHE147 3.4 13.7 1.0 ND2 A:ASN179 3.5 14.6 1.0 CB A:ASN179 3.5 11.0 1.0 CA A:GLN146 3.7 13.6 1.0 CB A:GLN146 3.8 14.5 1.0 CD2 A:PHE147 3.8 12.7 1.0 O A:HOH2056 3.9 45.8 1.0 C18 A:ZX1600 4.0 21.9 1.0 C A:GLN146 4.0 13.2 1.0 CG A:ASN179 4.0 13.1 1.0 CE2 A:TYR249 4.1 12.4 1.0 CB A:PHE147 4.2 13.9 1.0 CG A:GLN146 4.3 18.1 1.0 CA A:PHE147 4.4 14.2 1.0 CD A:PRO180 4.4 10.8 1.0 CG A:PHE147 4.5 13.4 1.0 O A:PRO243 4.5 10.2 1.0 C17 A:ZX1600 4.7 20.9 1.0 CE2 A:PHE147 4.7 11.8 1.0 OH A:TYR249 4.8 12.0 1.0 O A:LEU145 4.8 12.7 1.0 CA A:ASN179 4.9 10.9 1.0 CZ A:TYR249 4.9 12.7 1.0 CD2 A:TYR249 4.9 12.5 1.0 N A:GLN146 5.0 13.0 1.0

T.A.Blizzard, H.Chen, S.Kim, J.Wu, K.Young, Y.Park, A.Ogawa, S.Raghoobar, R.E.Painter, N.Hairston, S.H.Lee, A.Misura, T.Felcetto, P.M.D.Fitzgerald, N.Sharma, J.Lu, S.Ha, E.Hickey, J.Hermes, M.L.Hammond. Side Chain Sar of Bicyclic Beta-Lactamase Inhibitors (Blis). 1. Discovery of A Class C Bli For Combination with Imipinem. Bioorg.Med.Chem.Lett. V. 20 918 2010.
ISSN: ISSN 0960-894X
PubMed: 20044254
DOI: 10.1016/J.BMCL.2009.12.069