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Atomistry » Chlorine » PDB 2wzc-2x81 » 2x39 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2wzc-2x81 » 2x39 » |
Chlorine in PDB 2x39: Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to PkbEnzymatic activity of Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb
All present enzymatic activity of Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb:
2.7.11.1; 2.7.11.26; Protein crystallography data
The structure of Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb, PDB code: 2x39
was solved by
T.G.Davies,
T.Mchardy,
J.J.Caldwell,
K.M.Cheung,
L.J.Hunter,
K.Taylor,
M.Rowlands,
R.Ruddle,
A.Henley,
A.D.Brandon,
M.Valenti,
L.Fazal,
L.Seavers,
F.I.Raynaud,
S.A.Eccles,
G.W.Aherne,
M.D.Garrett,
I.Collins,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb
(pdb code 2x39). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb, PDB code: 2x39: Chlorine binding site 1 out of 1 in 2x39Go back to Chlorine Binding Sites List in 2x39
Chlorine binding site 1 out
of 1 in the Structure of 4-Amino-N-(4-Chlorobenzyl)-1-(7H-Pyrrolo(2,3-D) Pyrimidin-4-Yl)Piperidine-4-Carboxamide Bound to Pkb
Mono view Stereo pair view
Reference:
T.Mchardy,
J.J.Caldwell,
K.M.Cheung,
L.J.Hunter,
K.Taylor,
M.Rowlands,
R.Ruddle,
A.Henley,
A.De Haven Brandon,
M.Valenti,
T.G.Davies,
L.Fazal,
L.Seavers,
F.I.Raynaud,
S.A.Eccles,
G.W.Aherne,
M.D.Garrett,
I.Collins.
Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin- 4-Yl)Piperidine-4-Carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt). J.Med.Chem. V. 53 2239 2010.
Page generated: Sat Dec 12 09:24:49 2020
ISSN: ISSN 0022-2623 PubMed: 20151677 DOI: 10.1021/JM901788J |
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