Chlorine in PDB 2x7a: Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain

The structure of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain, PDB code: 2x7a was solved by G.Natrajan, A.A.Mccarthy, W.Weissenhorn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.880 / 2.77
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	169.890, 85.930, 123.310, 90.00, 126.94, 90.00
R / Rfree (%)	23.64 / 27.28

The structure of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Sodium	(Na)	7 atoms

The binding sites of Chlorine atom in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain (pdb code 2x7a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain, PDB code: 2x7a:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1149 b:0.4 occ:1.00 NA B:NA1148 3.5 98.5 1.0 CD2 B:LEU102 3.7 56.9 1.0 OG A:SER101 3.7 52.1 1.0 CG2 G:THR90 4.4 37.6 1.0 CB A:SER101 4.4 37.7 1.0 CD1 A:LEU98 4.7 32.9 1.0 O B:HOH2005 4.8 81.1 1.0

Chlorine binding site 2 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl1147 b:0.5 occ:1.00 NA F:NA1148 3.6 86.4 1.0 NE2 E:GLN108 3.9 78.1 1.0 C F:GLY109 4.0 45.6 1.0 OE2 E:GLU105 4.1 47.0 1.0 CA F:GLY109 4.1 37.7 1.0 O F:GLY109 4.2 45.9 1.0 N F:GLN110 4.3 48.9 1.0 CA E:GLY109 4.4 43.9 1.0 CG2 F:VAL113 4.7 38.1 1.0 CA F:GLN110 4.7 56.4 1.0 CG E:GLN108 4.7 81.8 1.0 CD E:GLN108 4.8 97.1 1.0 CB F:GLN110 4.9 0.1 1.0 O F:LYS106 4.9 45.4 1.0 N E:GLY109 5.0 45.5 1.0

Chlorine binding site 3 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl1149 b:0.6 occ:1.00 CB F:ALA89 3.3 41.6 1.0 N F:ALA89 3.7 41.2 1.0 NA D:NA1143 3.9 0.9 1.0 CA F:ALA89 4.1 43.5 1.0

Chlorine binding site 4 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl1143 b:96.0 occ:1.00 C3 G:GOL1142 3.5 0.7 1.0 OG1 A:THR94 3.7 41.0 1.0 O3 G:GOL1142 3.7 0.7 1.0 CA A:THR94 4.3 52.4 1.0 CB A:THR94 4.4 35.8 1.0 CG2 A:THR94 4.4 19.5 1.0 CD2 G:LEU98 4.6 22.6 1.0 N A:THR94 4.8 65.9 1.0 CB A:ALA97 4.9 42.5 1.0 C2 G:GOL1142 5.0 0.7 1.0

Chlorine binding site 5 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl1144 b:93.1 occ:1.00 NE2 G:GLN110 3.2 0.7 1.0 NA G:NA1145 3.6 81.3 1.0 CB G:LYS106 3.9 56.9 1.0 C G:LYS106 4.0 59.2 1.0 N G:ALA107 4.0 37.1 1.0 O G:LYS106 4.1 56.1 1.0 CA G:ALA107 4.1 42.5 1.0 CD G:GLN110 4.4 0.0 1.0 CA G:LYS106 4.6 50.8 1.0 CG G:GLN110 4.6 85.4 1.0 CE G:LYS106 4.8 54.2 1.0 CB G:ALA107 4.8 35.5 1.0 O G:HOH2005 4.9 56.4 1.0

Chlorine binding site 6 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl1145 b:97.3 occ:1.00 NA H:NA1144 3.7 83.1 1.0 OG1 H:THR94 4.0 44.2 1.0 CD1 E:LEU98 4.0 14.8 1.0 CA H:THR94 4.6 53.7 1.0 CB H:THR94 4.7 36.8 1.0 OG E:SER101 4.7 55.6 1.0 CG2 H:THR94 4.7 14.3 1.0

Chlorine binding site 7 out of 7 in the Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Structural Basis of Hiv-1 Tethering to Membranes By the BST2-Tetherin Ectodomain within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl1149 b:98.2 occ:1.00 NA J:NA1148 3.2 86.2 1.0 CD1 I:LEU98 4.0 20.7 1.0

A.Hinz, N.Miguet, G.Natrajan, Y.Usami, H.Yamanaka, P.Renesto, B.Hartlieb, A.A.Mccarthy, J.P.Simorre, H.Gottlinger, W.Weissenhorn. Structural Basis of Hiv-1 Tethering to Membranes By the Bst-2/Tetherin Ectodomain. Cell Host Microbe V. 7 314 2010.
ISSN: ISSN 1931-3128
PubMed: 20399176
DOI: 10.1016/J.CHOM.2010.03.005