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Chlorine in PDB 2x7g: Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B

Enzymatic activity of Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B

All present enzymatic activity of Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B:
2.7.11.1;

Protein crystallography data

The structure of Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B, PDB code: 2x7g was solved by A.C.W.Pike, P.Savitsky, O.Fedorov, T.Krojer, E.Ugochukwu, F.Von Delft, O.Gileadi, A.Edwards, C.H.Arrowsmith, J.Weigelt, C.Bountra, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.00 / 2.50
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 110.310, 110.310, 90.590, 90.00, 90.00, 120.00
R / Rfree (%) 18.3 / 24.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B (pdb code 2x7g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B, PDB code: 2x7g:

Chlorine binding site 1 out of 1 in 2x7g

Go back to Chlorine Binding Sites List in 2x7g
Chlorine binding site 1 out of 1 in the Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Serine-Arginine-Rich Protein-Specific Kinase 2 (SRPK2) Bound to Purvalanol B within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl800

b:72.2
occ:1.00
 CL1 A:PVB800 0.0 72.2 1.0
C5A A:PVB800 1.8 40.4 1.0
C6A A:PVB800 2.7 22.9 1.0
C4A A:PVB800 2.8 43.1 1.0
CX A:PVB800 3.1 51.2 1.0
OH A:TYR239 3.2 63.9 1.0
OX2 A:PVB800 3.5 51.3 1.0
OX1 A:PVB800 3.6 43.9 1.0
CE A:MET243 3.7 33.2 1.0
SD A:MET243 3.8 55.8 1.0
C1A A:PVB800 4.0 23.6 1.0
CE2 A:TYR239 4.1 58.3 1.0
CZ A:TYR239 4.1 54.5 1.0
C3A A:PVB800 4.1 33.2 1.0
NE2 A:HIS182 4.2 43.5 1.0
CE1 A:HIS182 4.2 48.1 1.0
C2A A:PVB800 4.6 37.3 1.0
CG A:MET243 4.6 54.9 1.0
ND1 A:HIS182 4.9 39.7 1.0
CD2 A:HIS182 4.9 43.4 1.0

Reference:

A.C.W.Pike, P.Savitsky, O.Fedorov, T.Krojer, E.Ugochukwu, F.Von Delft, O.Gileadi, A.Edwards, C.H.Arrowsmith, J.Weigelt, C.Bountra, S.Knapp. Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (SRPK2) Bound to Purvalanol B To Be Published.
Page generated: Fri Jul 11 01:48:13 2025

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