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Atomistry » Chlorine » PDB 2xep-2xmb » 2xk4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2xep-2xmb » 2xk4 » |
Chlorine in PDB 2xk4: Structure of NEK2 Bound to Aminopyrazine Compound 17Enzymatic activity of Structure of NEK2 Bound to Aminopyrazine Compound 17
All present enzymatic activity of Structure of NEK2 Bound to Aminopyrazine Compound 17:
2.7.11.1; Protein crystallography data
The structure of Structure of NEK2 Bound to Aminopyrazine Compound 17, PDB code: 2xk4
was solved by
C.Mas-Droux,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of NEK2 Bound to Aminopyrazine Compound 17
(pdb code 2xk4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Structure of NEK2 Bound to Aminopyrazine Compound 17, PDB code: 2xk4: Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; Chlorine binding site 1 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 1 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Chlorine binding site 2 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 2 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Chlorine binding site 3 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 3 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Chlorine binding site 4 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 4 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Chlorine binding site 5 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 5 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Chlorine binding site 6 out of 6 in 2xk4Go back to Chlorine Binding Sites List in 2xk4
Chlorine binding site 6 out
of 6 in the Structure of NEK2 Bound to Aminopyrazine Compound 17
Mono view Stereo pair view
Reference:
D.K.Whelligan,
S.Solanki,
D.Taylor,
D.W.Thomson,
K.M.Cheung,
K.Boxall,
C.Mas-Droux,
C.Barillari,
S.Burns,
C.G.Grummitt,
I.Collins,
R.L.Van Montfort,
G.W.Aherne,
R.Bayliss,
S.Hoelder.
Aminopyrazine Inhibitors Binding to An Unusual Inactive Conformation of the Mitotic Kinase NEK2: Sar and Structural Characterization. J.Med.Chem. V. 53 7682 2010.
Page generated: Sat Dec 12 09:26:08 2020
ISSN: ISSN 0022-2623 PubMed: 20936789 DOI: 10.1021/JM1008727 |
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