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Atomistry » Chlorine » PDB 2xmc-2xs4 » 2xnp | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2xmc-2xs4 » 2xnp » |
Chlorine in PDB 2xnp: Structure of NEK2 Bound to CCT244858Enzymatic activity of Structure of NEK2 Bound to CCT244858
All present enzymatic activity of Structure of NEK2 Bound to CCT244858:
2.7.11.1; Protein crystallography data
The structure of Structure of NEK2 Bound to CCT244858, PDB code: 2xnp
was solved by
C.Mas-Droux,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2xnp:
The structure of Structure of NEK2 Bound to CCT244858 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of NEK2 Bound to CCT244858
(pdb code 2xnp). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of NEK2 Bound to CCT244858, PDB code: 2xnp: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 2xnpGo back to Chlorine Binding Sites List in 2xnp
Chlorine binding site 1 out
of 4 in the Structure of NEK2 Bound to CCT244858
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 2xnpGo back to Chlorine Binding Sites List in 2xnp
Chlorine binding site 2 out
of 4 in the Structure of NEK2 Bound to CCT244858
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 2xnpGo back to Chlorine Binding Sites List in 2xnp
Chlorine binding site 3 out
of 4 in the Structure of NEK2 Bound to CCT244858
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 2xnpGo back to Chlorine Binding Sites List in 2xnp
Chlorine binding site 4 out
of 4 in the Structure of NEK2 Bound to CCT244858
Mono view Stereo pair view
Reference:
S.Solanki,
P.Innocenti,
C.Mas-Droux,
K.Boxall,
C.Barillari,
R.L.Van Montfort,
G.W.Aherne,
R.Bayliss,
S.Hoelder.
Benzimidazole Inhibitors Induce A Dfg-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (NEK2) Without Binding to the Back Pocket and Reveal A Nonlinear Structure-Activity Relationship. J.Med.Chem. V. 54 1626 2011.
Page generated: Sat Dec 12 09:26:30 2020
ISSN: ISSN 0022-2623 PubMed: 21366329 DOI: 10.1021/JM1011726 |
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