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Atomistry » Chlorine » PDB 2xs6-2xzc » 2xyn | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2xs6-2xzc » 2xyn » |
Chlorine in PDB 2xyn: Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680Enzymatic activity of Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680
All present enzymatic activity of Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680:
2.7.10.2; Protein crystallography data
The structure of Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680, PDB code: 2xyn
was solved by
E.Salah,
E.Ugochukwu,
J.M.Elkins,
A.J.Barr,
B.Shrestha,
P.Savitsky,
P.Mahajan,
J.R.C.Muniz,
W.W.Yue,
A.Chaikuad,
F.Von Delft,
C.Bountra,
C.H.Arrowsmith,
J.Weigelt,
A.Edwards,
S.Knapp,
Structural Genomicsconsortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2xyn:
The structure of Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680
(pdb code 2xyn). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680, PDB code: 2xyn: Chlorine binding site 1 out of 1 in 2xynGo back to Chlorine Binding Sites List in 2xyn
Chlorine binding site 1 out
of 1 in the Human ABL2 in Complex with Aurora Kinase Inhibitor Vx-680
Mono view Stereo pair view
Reference:
E.Salah,
E.Ugochukwu,
A.J.Barr,
F.Von Delft,
S.Knapp,
J.M.Elkins.
Crystal Structures of Abl-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (Vx-680), and A Type I Inhibitor of the Triazole Carbothioamide Class. J.Med.Chem. V. 54 2359 2011.
Page generated: Sat Dec 12 09:27:17 2020
ISSN: ISSN 0022-2623 PubMed: 21417343 DOI: 10.1021/JM101506N |
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