Atomistry » Chlorine » PDB 2xzr-2y58 » 2y05
Atomistry »
  Chlorine »
    PDB 2xzr-2y58 »
      2y05 »

Chlorine in PDB 2y05: Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene

Enzymatic activity of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene

All present enzymatic activity of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene:
1.3.1.48; 1.3.1.74;

Protein crystallography data

The structure of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene, PDB code: 2y05 was solved by W.W.Yue, N.Shafqat, T.Krojer, A.C.W.Pike, F.Von Delft, R.Sethi, P.Savitsky, C.Johansson, C.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.55 / 2.20
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 93.274, 116.599, 154.607, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 23.1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene (pdb code 2y05). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene, PDB code: 2y05:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 2y05

Go back to Chlorine Binding Sites List in 2y05
Chlorine binding site 1 out of 5 in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1330

b:62.7
occ:1.00
 OG A:SER88 2.9 25.5 1.0
N A:SER88 3.6 23.7 1.0
C A:ALA87 3.6 24.2 1.0
CA A:ALA87 3.6 24.0 1.0
NE2 A:GLN66 3.7 18.2 1.0
O A:LEU86 3.7 25.2 1.0
N A:ALA87 3.8 24.1 1.0
CB A:SER88 3.8 24.6 1.0
O A:ASP101 3.9 39.8 1.0
C A:LEU86 3.9 24.7 1.0
C29 A:RAL801 4.1 52.0 1.0
CG A:GLN66 4.3 22.4 1.0
O A:ALA87 4.3 24.0 1.0
CA A:SER88 4.3 24.0 1.0
C30 A:RAL801 4.5 49.9 1.0
CD A:GLN66 4.5 19.3 1.0
CB A:LEU86 4.6 24.7 1.0
CA A:LEU86 4.9 25.4 1.0

Chlorine binding site 2 out of 5 in 2y05

Go back to Chlorine Binding Sites List in 2y05
Chlorine binding site 2 out of 5 in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1333

b:64.6
occ:1.00
 O11 A:RAL801 3.5 28.9 1.0
C12 A:RAL801 4.0 23.6 1.0
C11 A:RAL801 4.1 26.3 1.0
CB B:ALA78 4.5 28.3 1.0

Chlorine binding site 3 out of 5 in 2y05

Go back to Chlorine Binding Sites List in 2y05
Chlorine binding site 3 out of 5 in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1330

b:34.6
occ:1.00
 NZ B:LYS100 2.9 52.7 1.0
CE B:LYS100 3.6 54.5 1.0
C25 A:RAL802 3.9 77.2 1.0
C31 A:RAL802 3.9 84.8 1.0
C27 A:RAL802 4.0 86.3 1.0
N26 A:RAL802 4.3 83.3 1.0
C29 A:RAL802 4.4 86.1 1.0
CD B:LYS100 4.5 49.6 1.0
C30 A:RAL802 4.7 85.0 1.0
C28 A:RAL802 4.7 87.6 1.0

Chlorine binding site 4 out of 5 in 2y05

Go back to Chlorine Binding Sites List in 2y05
Chlorine binding site 4 out of 5 in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1331

b:64.5
occ:1.00
 NZ B:LYS289 3.2 36.8 1.0
NE1 B:TRP290 3.7 30.6 1.0
CE B:LYS289 4.4 43.5 1.0
CE2 B:TRP290 4.5 27.4 1.0
CZ2 B:TRP290 4.5 27.8 1.0
NZ B:LYS295 4.5 51.5 1.0
CD1 B:TRP290 4.8 25.5 1.0

Chlorine binding site 5 out of 5 in 2y05

Go back to Chlorine Binding Sites List in 2y05
Chlorine binding site 5 out of 5 in the Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1333

b:59.5
occ:1.00
 N C:GLU59 3.6 30.8 1.0
CA C:LYS58 4.0 32.5 1.0
CG C:GLU59 4.0 38.2 1.0
C C:LYS58 4.3 30.6 1.0
CB C:GLU59 4.3 32.6 1.0
NE2 C:HIS12 4.3 28.4 1.0
CB C:LYS58 4.4 33.9 1.0
CD C:GLU59 4.4 49.2 1.0
CA C:GLU59 4.6 30.9 1.0
CG C:LYS58 4.6 37.3 1.0
CD2 C:HIS12 4.7 24.9 1.0
O C:HOH2017 4.7 37.4 1.0
OE2 C:GLU59 4.7 52.1 1.0
O C:LEU57 4.8 30.9 1.0
OE1 C:GLU59 5.0 49.1 1.0

Reference:

W.W.Yue, N.Shafqat, T.Krojer, A.C.W.Pike, F.Von Delft, R.Sethi, P.Savitsky, C.Johansson, C.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann. Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene To Be Published.
Page generated: Fri Jul 11 02:13:50 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy