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Chlorine in PDB 2y1d: X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.
Enzymatic activity of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.
All present enzymatic activity of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.:
1.1.1.267;
1.1.1.267;
Protein crystallography data
The structure of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese., PDB code: 2y1d
was solved by
L.M.Henriksson,
A.M.S.Larsson,
T.Bergfors,
C.Bjorkelid,
T.Unge,
S.L.Mowbray,
T.A.Jones,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.00 / 2.05 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 69.622, 67.318, 84.301, 90.00, 107.38, 90.00 |
| R / Rfree (%) | 20.9 / 26.1 |
Other elements in 2y1d:
The structure of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese. also contains other interesting chemical elements:
| Manganese | (Mn) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.
(pdb code 2y1d). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese., PDB code: 2y1d:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese., PDB code: 2y1d:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 2y1d
Go back to
Chlorine Binding Sites List in 2y1d
Chlorine binding site 1 out
of 2 in the X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese. within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 2y1d
Go back to
Chlorine Binding Sites List in 2y1d
Chlorine binding site 2 out
of 2 in the X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of X-Ray Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Dxr, RV2870C, From Mycobacterium Tuberculosis, in Complex with A 3,4- Dichlorophenyl-Substituted Fosmidomycin Analogue and Manganese. within 5.0Å range:
|
Reference:
M.Andaloussi,
L.M.Henriksson,
A.Wieckowska,
M.Lindh,
C.Bjorkelid,
A.M.S.Larsson,
H.Iyer,
B.R.Srinivasa,
T.Bergfors,
T.Unge,
S.L.Mowbray,
M.Larhed,
T.A.Jones,
A.Karlen.
Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues As Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase J.Med.Chem V. 54 4964 2011.
ISSN: ISSN 0022-2623
PubMed: 21678907
DOI: 10.1021/JM2000085
Page generated: Sat Jul 20 14:22:04 2024
ISSN: ISSN 0022-2623
PubMed: 21678907
DOI: 10.1021/JM2000085
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