Chlorine in PDB 2y4i: KSR2-MEK1 Heterodimer

All present enzymatic activity of KSR2-MEK1 Heterodimer:
2.7.12.2;

The structure of KSR2-MEK1 Heterodimer, PDB code: 2y4i was solved by D.F.Brennan, D.Barford, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.86 / 3.46
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	130.565, 130.565, 221.005, 90.00, 90.00, 120.00
R / Rfree (%)	23 / 29.3

The structure of KSR2-MEK1 Heterodimer also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Chlorine atom in the KSR2-MEK1 Heterodimer (pdb code 2y4i). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the KSR2-MEK1 Heterodimer, PDB code: 2y4i:

Chlorine binding site 1 out of 1 in the KSR2-MEK1 Heterodimer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of KSR2-MEK1 Heterodimer within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1384 b:1.0 occ:1.00 O C:ALA347 3.4 0.7 1.0 OD2 C:ASP351 4.2 0.9 1.0 NE2 C:GLN354 4.4 0.2 1.0 O C:ARG349 4.5 0.9 1.0 C C:ALA347 4.5 0.2 1.0 NE2 C:GLN243 4.9 0.9 1.0

D.F.Brennan, A.C.Dar, N.T.Hertz, W.Chao, A.L.Burlingame, K.M.Shokat, D.Barford. A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature V. 472 366 2011.
ISSN: ISSN 0028-0836
PubMed: 21441910
DOI: 10.1038/NATURE09860