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Chlorine in PDB 2zb8: Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin

Enzymatic activity of Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin

All present enzymatic activity of Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin:
1.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin, PDB code: 2zb8 was solved by Y.H.Wu, A.H.J.Wang, T.P.Ko, R.T.Guo, S.M.Hu, L.M.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.00
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 68.482, 84.079, 73.318, 90.00, 109.48, 90.00
R / Rfree (%) 17.1 / 21.8

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin (pdb code 2zb8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin, PDB code: 2zb8:

Chlorine binding site 1 out of 1 in 2zb8

Go back to Chlorine Binding Sites List in 2zb8
Chlorine binding site 1 out of 1 in the Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human 15-Ketoprostaglandin Delta-13- Reductase in Complex with Nadp and Indomethacin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl800

b:75.3
occ:1.00
 CL A:IMN800 0.0 75.3 1.0
C13 A:IMN800 1.1 75.5 1.0
C14 A:IMN800 2.2 75.6 1.0
C12 A:IMN800 2.2 75.6 1.0
CE1 A:TYR100 3.0 57.2 1.0
O A:HOH1477 3.0 73.7 1.0
CZ A:TYR100 3.0 57.9 1.0
OH A:TYR100 3.1 62.2 1.0
C15 A:IMN800 3.5 76.3 1.0
C11 A:IMN800 3.5 75.9 1.0
CD1 A:TYR100 3.7 54.7 1.0
CE2 A:TYR100 3.8 57.4 1.0
C10 A:IMN800 3.9 76.2 1.0
CD1 A:ILE65 4.0 68.5 1.0
CB A:PHE99 4.1 48.9 1.0
O A:HOH1478 4.3 79.7 1.0
O A:PHE99 4.3 42.5 1.0
CG A:TYR100 4.4 51.1 1.0
CD2 A:TYR100 4.5 53.8 1.0
C A:PHE99 4.7 43.2 1.0
CG1 A:ILE65 4.8 68.6 1.0

Reference:

Y.H.Wu, T.P.Ko, R.T.Guo, S.M.Hu, L.M.Chuang, A.H.J.Wang. Structural Basis For Catalytic and Inhibitory Mechanisms of Human Prostaglandin Reductase PTGR2. Structure V. 16 1714 2008.
ISSN: ISSN 0969-2126
PubMed: 19000823
DOI: 10.1016/J.STR.2008.09.007
Page generated: Fri Jul 11 02:53:29 2025

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