Chlorine in PDB 3apx: Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex

The structure of Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex, PDB code: 3apx was solved by K.Nishi, T.Ono, T.Nakamura, N.Fukunaga, M.Izumi, H.Watanabe, A.Suenaga, T.Maruyama, Y.Yamagata, S.Curry, M.Otagiri, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.88 / 2.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.125, 63.077, 64.957, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 26.8

The binding sites of Chlorine atom in the Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex (pdb code 3apx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex, PDB code: 3apx:

Chlorine binding site 1 out of 1 in the Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the A Variant of Human ALPHA1-Acid Glycoprotein and Chlorpromazine Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl190 b:31.9 occ:1.00 CL1 A:Z80190 0.0 31.9 1.0 C10 A:Z80190 1.8 30.9 1.0 C11 A:Z80190 2.7 30.8 1.0 C9 A:Z80190 2.8 30.7 1.0 CD1 A:PHE49 3.7 7.0 1.0 CE1 A:PHE49 3.8 6.8 1.0 OE2 A:GLU64 3.9 16.0 1.0 CE2 A:TYR127 3.9 5.7 1.0 OH A:TYR127 3.9 8.1 1.0 CD A:GLU64 3.9 14.2 1.0 CG2 A:THR47 4.0 6.8 1.0 C4 A:Z80190 4.1 30.8 1.0 C8 A:Z80190 4.1 30.2 1.0 OE1 A:GLU64 4.2 14.5 1.0 NH2 A:ARG90 4.2 23.7 1.0 CZ A:TYR127 4.4 5.9 1.0 O A:HOH263 4.4 22.6 1.0 CG A:GLU64 4.4 11.2 1.0 C3 A:Z80190 4.6 30.5 1.0 CG A:PHE49 4.6 7.3 1.0 CB A:THR47 4.8 7.3 1.0 CZ A:PHE49 4.8 6.8 1.0 CD2 A:TYR127 4.9 4.9 1.0

K.Nishi, T.Ono, T.Nakamura, N.Fukunaga, M.Izumi, H.Watanabe, A.Suenaga, T.Maruyama, Y.Yamagata, S.Curry, M.Otagiri. Structural Insights Into Differences in Drug-Binding Selectivity Between Two Forms of Human ALPHA1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms. J. Biol. Chem. V. 286 14427 2011.
ISSN: ESSN 1083-351X
PubMed: 21349832
DOI: 10.1074/JBC.M110.208926