Chlorine in PDB 3c44: Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin

The structure of Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin, PDB code: 3c44 was solved by S.Freisz, E.Ennifar, P.Dumas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.55 / 2.00
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	30.818, 95.703, 47.856, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 24.7

The structure of Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin also contains other interesting chemical elements:

Potassium

(K)

4 atoms

The binding sites of Chlorine atom in the Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin (pdb code 3c44). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin, PDB code: 3c44:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl26 b:77.0 occ:1.00 N2 A:G10 3.4 24.9 1.0 O4' A:U11 3.7 28.3 1.0 C1' A:U11 3.9 26.6 1.0 O B:HOH76 3.9 49.5 1.0 N3 A:G10 4.3 26.1 1.0 C2 A:G10 4.3 26.1 1.0 C4' A:U11 4.7 27.4 1.0 O2' A:U11 4.7 27.0 1.0 C1' B:A16 4.7 35.4 1.0 N1 A:U11 4.8 25.8 1.0 O2' B:A16 4.8 39.4 1.0 O4' B:A16 4.9 36.5 1.0 C2' A:U11 5.0 25.9 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Hiv-1 Subtype F Dis Extended Duplex Rna Bound to Paromomycin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl27 b:59.2 occ:1.00 O B:HOH48 2.9 46.7 1.0 N2 B:G10 3.0 21.2 1.0 O4' B:U11 3.8 25.5 1.0 C1' B:U11 3.8 24.9 1.0 C2 B:G10 3.9 26.1 1.0 N3 B:G10 3.9 27.4 1.0 O A:HOH48 4.0 41.6 1.0 C1' A:A16 4.1 28.0 1.0 O A:HOH40 4.1 36.9 1.0 O2' A:A16 4.2 28.7 1.0 O4' A:A16 4.3 28.7 1.0 O B:HOH95 4.3 40.9 1.0 O2' B:U11 4.6 24.0 1.0 N1 B:U11 4.6 24.2 1.0 O2 A:C15 4.8 23.3 1.0 C2' A:A16 4.8 28.6 1.0 O2 B:U11 4.8 23.8 1.0 O B:HOH32 4.9 27.6 1.0 C4' B:U11 4.9 25.7 1.0 C2' B:U11 4.9 25.8 1.0

S.Freisz, K.Lang, R.Micura, P.Dumas, E.Ennifar. Binding of Aminoglycoside Antibiotics to the Duplex Form of the Hiv-1 Genomic Rna Dimerization Initiation Site. Angew.Chem.Int.Ed.Engl. V. 47 4110 2008.
ISSN: ISSN 0570-0833
PubMed: 18435520
DOI: 10.1002/ANIE.200800726