Chlorine in PDB 3c4w: Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A

Enzymatic activity of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A

All present enzymatic activity of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A:
2.7.11.14;

Protein crystallography data

The structure of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A, PDB code: 3c4w was solved by P.Singh, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.98 / 2.70
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	202.889, 55.054, 122.699, 90.00, 100.82, 90.00
*R / R_free (%)*	19.2 / n/a

Other elements in 3c4w:

The structure of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A (pdb code 3c4w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A, PDB code: 3c4w:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 3c4w

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Chlorine Binding Sites List in 3c4w

Chlorine binding site 1 out of 3 in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl565 b:21.4 occ:1.00	N	A:LEU166	3.3	13.2	1.0
	NE2	B:GLN173	3.5	12.3	1.0
	CB	A:SER165	3.5	13.3	1.0
	NH1	B:ARG170	3.6	26.8	1.0
	O	A:HOH670	3.6	14.2	1.0
	CA	A:SER165	3.7	13.3	1.0
	CG	A:LEU166	3.9	10.1	1.0
	C	A:SER165	4.0	13.9	1.0
	CB	A:LEU166	4.0	12.2	1.0
	NH2	B:ARG170	4.3	23.6	1.0
	CA	A:LEU166	4.3	12.5	1.0
	CZ	B:ARG170	4.4	19.9	1.0
	CD	B:GLN173	4.5	16.5	1.0
	CD1	A:TYR167	4.5	10.5	1.0
	CE1	A:TYR167	4.5	10.4	1.0
	CD1	A:LEU166	4.5	8.6	1.0
	OE1	B:GLN173	4.6	19.0	1.0
	OG	A:SER165	4.6	8.5	1.0
	CD2	B:LEU44	5.0	16.8	1.0
	N	A:TYR167	5.0	12.1	1.0

Chlorine binding site 2 out of 3 in 3c4w

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Chlorine Binding Sites List in 3c4w

Chlorine binding site 2 out of 3 in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl566 b:23.0 occ:1.00	N	A:GLN287	3.2	27.2	1.0
	CD	A:ARG290	3.4	21.7	1.0
	NH1	A:ARG290	3.5	26.8	1.0
	CA	A:PHE286	3.6	28.0	1.0
	C	A:PHE286	3.9	26.9	1.0
	CG	A:GLN287	3.9	29.4	1.0
	CB	A:PHE286	4.1	27.6	1.0
	CD2	A:PHE286	4.1	26.1	1.0
	CB	A:GLN287	4.2	26.7	1.0
	CG2	A:VAL279	4.2	37.1	1.0
	CA	A:GLN287	4.3	27.0	1.0
	NE	A:ARG290	4.3	26.0	1.0
	O	A:GLY285	4.4	30.3	1.0
	CZ	A:ARG290	4.4	26.7	1.0
	CB	A:ARG290	4.4	21.9	1.0
	CG	A:ARG290	4.5	21.5	1.0
	CG	A:PHE286	4.5	27.2	1.0
	N	A:PHE286	4.7	28.8	1.0
	C	A:GLY285	5.0	29.8	1.0

Chlorine binding site 3 out of 3 in 3c4w

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Chlorine Binding Sites List in 3c4w

Chlorine binding site 3 out of 3 in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Atp and Magnesium Chloride at 2.7A within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl567 b:16.3 occ:1.00	NE2	A:GLN173	3.2	11.3	1.0
	NH2	A:ARG170	3.5	21.1	1.0
	N	B:LEU166	3.6	13.2	1.0
	CG	B:LEU166	3.8	11.6	1.0
	CB	B:LEU166	3.9	12.0	1.0
	CD1	B:LEU166	4.0	9.1	1.0
	OE1	A:GLN173	4.1	15.7	1.0
	CD	A:GLN173	4.1	15.7	1.0
	CB	B:SER165	4.1	13.5	1.0
	O	B:HOH619	4.2	28.2	1.0
	CA	B:SER165	4.3	13.4	1.0
	CA	B:LEU166	4.3	12.5	1.0
	C	B:SER165	4.5	14.0	1.0
	CE1	B:TYR167	4.5	8.9	1.0
	CZ	A:ARG170	4.5	17.4	1.0
	CD1	B:TYR167	4.6	9.4	1.0
	NE	A:ARG170	4.7	18.7	1.0
	OG	B:SER165	4.8	8.8	1.0

Reference:

P.Singh, B.Wang, T.Maeda, K.Palczewski, J.J.Tesmer. Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-Coupled Receptor Kinase Activation. J.Biol.Chem. V. 283 14053 2008.
ISSN: ISSN 0021-9258
PubMed: 18339619
DOI: 10.1074/JBC.M708974200

Page generated: Fri Jul 11 03:36:54 2025

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