Chlorine in PDB 3c4z: Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A

All present enzymatic activity of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A:
2.7.11.14;

The structure of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A, PDB code: 3c4z was solved by P.Singh, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.47 / 1.84
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	65.540, 82.947, 107.144, 90.00, 93.01, 90.00
R / Rfree (%)	19.3 / n/a

The structure of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Chlorine atom in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A (pdb code 3c4z). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A, PDB code: 3c4z:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl565 b:37.1 occ:1.00 O A:HOH654 3.1 40.4 1.0 N A:LEU166 3.3 26.3 1.0 CG A:LEU166 3.7 28.9 1.0 CB A:LEU166 3.8 27.9 1.0 CB A:SER165 3.9 26.9 1.0 CA A:SER165 4.0 27.5 1.0 C A:SER165 4.1 26.9 1.0 CA A:LEU166 4.1 26.4 1.0 CE1 A:TYR167 4.3 30.4 1.0 CD1 A:LEU166 4.4 28.1 1.0 CD1 A:TYR167 4.4 29.0 1.0 CD2 A:LEU166 4.8 25.0 1.0 OG A:SER165 4.8 28.4 1.0 CE1 A:HIS79 4.9 50.0 1.0 N A:TYR167 4.9 24.2 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of G Protein Coupled Receptor Kinase 1 Bound to Adp and Magnesium Chloride at 1.84A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl566 b:29.8 occ:1.00 O A:HOH636 3.2 33.9 1.0 O A:HOH779 3.2 39.8 1.0 N A:PHE389 3.2 30.7 1.0 NE A:ARG390 3.3 28.4 1.0 N A:ARG390 3.4 29.7 1.0 NH2 A:ARG390 3.5 31.4 1.0 CA A:GLY387 3.6 31.7 1.0 C A:GLY387 3.6 30.7 1.0 CB A:PHE389 3.7 32.1 1.0 N A:PRO388 3.8 31.6 1.0 CA A:PHE389 3.8 30.8 1.0 CZ A:ARG390 3.9 31.8 1.0 CD A:PRO388 3.9 31.5 1.0 C A:PHE389 3.9 30.4 1.0 CB A:ARG390 4.0 30.1 1.0 CD1 A:PHE389 4.0 37.7 1.0 O A:GLY387 4.2 31.4 1.0 O A:HOH879 4.2 42.2 1.0 CG A:PHE389 4.2 32.7 1.0 CA A:ARG390 4.3 30.1 1.0 CG A:ARG390 4.3 30.4 1.0 C A:PRO388 4.3 31.0 1.0 CD A:ARG390 4.4 30.1 1.0 N A:GLY387 4.5 31.0 1.0 CA A:PRO388 4.6 31.5 1.0 O A:ARG390 4.6 32.1 1.0 O A:HOH680 4.7 37.9 1.0 CG A:PRO388 4.7 32.6 1.0 CA A:GLY354 5.0 30.5 1.0 C A:ARG390 5.0 30.9 1.0 O A:PHE389 5.0 30.9 1.0 O A:HOH780 5.0 39.7 1.0

P.Singh, B.Wang, T.Maeda, K.Palczewski, J.J.Tesmer. Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-Coupled Receptor Kinase Activation. J.Biol.Chem. V. 283 14053 2008.
ISSN: ISSN 0021-9258
PubMed: 18339619
DOI: 10.1074/JBC.M708974200