Atomistry » Chlorine » PDB 3c4w-3ccl » 3c5e
Atomistry »
  Chlorine »
    PDB 3c4w-3ccl »
      3c5e »

Chlorine in PDB 3c5e: Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp

Enzymatic activity of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp

All present enzymatic activity of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp:
6.2.1.2;

Protein crystallography data

The structure of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp, PDB code: 3c5e was solved by E.S.Pilka, G.T.Kochan, C.Bhatia, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, J.Weigelt, C.Bountra, U.Oppermann, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.00 / 1.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.700, 98.073, 120.263, 90.00, 90.00, 90.00
R / Rfree (%) 15.6 / 19.4

Other elements in 3c5e:

The structure of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp (pdb code 3c5e). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp, PDB code: 3c5e:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3c5e

Go back to Chlorine Binding Sites List in 3c5e
Chlorine binding site 1 out of 2 in the Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl703

b:11.4
occ:0.50
 O A:LYS290 2.1 30.4 0.5
O A:HOH1002 3.0 22.4 1.0
C A:LYS290 3.1 23.8 0.5
N A:LYS290 3.2 18.1 1.0
O A:HOH1044 3.3 21.2 1.0
CD1 A:LEU288 3.4 18.5 0.4
N A:PHE291 3.6 14.7 0.5
CA A:LYS290 3.6 21.8 0.5
CD A:PRO289 3.7 15.3 1.0
C A:LEU288 3.7 13.9 1.0
CA A:LEU288 3.7 14.0 0.4
N A:PRO289 3.7 13.7 1.0
CA A:LEU288 3.7 16.3 0.6
CA A:LYS290 3.7 18.7 0.5
N A:ASP292 3.7 21.5 1.0
CB A:LYS290 3.8 21.9 1.0
CB A:ASP292 3.8 22.9 1.0
C A:LYS290 3.9 17.9 0.5
CG A:LEU288 4.0 9.7 0.4
CD2 A:LEU288 4.0 17.1 0.6
CG2 A:VAL295 4.1 17.6 1.0
CG A:PRO289 4.2 18.5 1.0
CG1 A:VAL295 4.2 17.3 1.0
CB A:VAL295 4.2 15.6 1.0
O A:LEU288 4.2 16.2 1.0
N A:PHE291 4.3 27.6 0.5
C A:PRO289 4.3 19.7 1.0
CA A:ASP292 4.4 21.2 1.0
CB A:LEU288 4.4 14.1 0.4
CA A:PHE291 4.5 16.9 0.5
CB A:LEU288 4.5 18.6 0.6
CA A:PRO289 4.5 18.8 1.0
CA A:PHE291 4.7 25.8 0.5
C A:PHE291 4.7 22.1 1.0
CG A:LYS290 4.7 25.3 1.0
O A:HOH1097 4.7 32.0 1.0
O A:LYS290 4.8 15.9 0.5
N A:LEU288 4.8 12.9 1.0
CG A:LEU288 4.9 26.6 0.6
O A:HOH1467 4.9 28.9 1.0
CB A:PRO289 5.0 19.5 1.0

Chlorine binding site 2 out of 2 in 3c5e

Go back to Chlorine Binding Sites List in 3c5e
Chlorine binding site 2 out of 2 in the Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Acyl-Coa Synthetase Medium-Chain Family Member 2A (L64P Mutation) in Complex with Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl704

b:21.5
occ:1.00
 OG1 A:THR345 2.9 18.0 1.0
N A:LEU342 3.2 17.0 1.0
NH1 A:ARG316 3.4 27.5 1.0
CB A:THR345 3.5 14.3 1.0
CG A:LEU342 3.7 23.6 1.0
CB A:LEU342 3.7 19.1 1.0
CB A:PRO312 3.8 15.8 1.0
CG2 A:THR345 3.9 16.7 1.0
CD A:ARG316 3.9 22.5 1.0
O A:SER340 3.9 21.7 1.0
CD1 A:LEU342 3.9 22.4 1.0
CG A:ARG316 4.0 18.2 1.0
CA A:LEU341 4.0 14.9 1.0
CD1 A:LEU341 4.0 18.2 1.0
CA A:LEU342 4.0 14.2 1.0
C A:LEU341 4.0 15.1 1.0
CZ A:ARG316 4.4 23.5 1.0
O A:HOH1143 4.5 43.5 1.0
NE A:ARG316 4.6 22.4 1.0
O A:LEU342 4.6 17.4 1.0
O A:PRO312 4.7 15.7 1.0
C A:SER340 4.8 21.6 1.0
CA A:PRO312 4.8 14.1 1.0
CG A:PRO312 4.8 18.3 1.0
N A:LEU341 4.8 16.9 1.0
C A:LEU342 4.9 14.8 1.0
CG A:LEU341 4.9 18.9 1.0
C A:PRO312 4.9 14.1 1.0
CA A:THR345 4.9 14.4 1.0
CB A:LEU341 5.0 16.3 1.0

Reference:

G.Kochan, E.S.Pilka, F.Von Delft, U.Oppermann, W.W.Yue. Structural Snapshots For the Conformation-Dependent Catalysis By Human Medium-Chain Acyl-Coenzyme A Synthetase ACSM2A. J.Mol.Biol. V. 388 997 2009.
ISSN: ISSN 0022-2836
PubMed: 19345228
DOI: 10.1016/J.JMB.2009.03.064
Page generated: Sat Jul 20 16:52:23 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy