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Chlorine in PDB 3ccr: Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.

Protein crystallography data

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model., PDB code: 3ccr was solved by G.Blaha, G.Gurel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.81 / 3.00
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 212.411, 299.520, 574.897, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 24.7

Other elements in 3ccr:

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. also contains other interesting chemical elements:

Strontium (Sr) 108 atoms
Magnesium (Mg) 93 atoms
Potassium (K) 2 atoms
Cadmium (Cd) 5 atoms
Sodium (Na) 75 atoms

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 22;

Binding sites:

The binding sites of Chlorine atom in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. (pdb code 3ccr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 22 binding sites of Chlorine where determined in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model., PDB code: 3ccr:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 1 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl8809

b:0.1
occ:1.00
 NZ A:LYS178 3.0 44.5 1.0
CE A:LYS175 3.3 38.7 1.0
O A:HOH9065 3.5 66.3 1.0
O 0:HOH4924 3.5 43.3 1.0
NZ A:LYS175 4.0 40.8 1.0
O 0:HOH6403 4.0 45.9 1.0
CE A:LYS178 4.3 43.6 1.0
O 0:HOH3245 4.3 28.6 1.0
CD A:LYS175 4.4 37.1 1.0
CE A:MET179 4.4 44.3 1.0
O 0:HOH3922 4.5 41.7 1.0
SD A:MET179 4.5 43.8 1.0
CD A:LYS178 4.5 42.6 1.0
OP2 0:G1878 4.9 51.4 1.0
CZ A:PHE169 4.9 52.4 1.0

Chlorine binding site 2 out of 22 in 3ccr

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Chlorine binding site 2 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl8819

b:59.9
occ:1.00
 O B:HOH8997 2.5 35.4 1.0
O 0:HOH9665 2.9 39.9 1.0
CD B:ARG223 3.3 48.7 1.0
O 0:HOH6156 3.3 67.8 1.0
CA B:ARG223 3.6 43.0 1.0
O B:HOH9056 3.6 21.8 1.0
CB B:HIS227 3.7 39.2 1.0
N B:LYS224 3.9 41.3 1.0
CB B:ARG223 3.9 45.1 1.0
CG B:HIS227 4.1 41.3 1.0
N2 0:G2613 4.1 44.7 1.0
O2' 0:U2545 4.1 43.9 1.0
CG B:ARG223 4.1 47.0 1.0
O4' 0:U2546 4.2 40.0 1.0
C4' 0:U2546 4.3 37.0 1.0
NE B:ARG223 4.3 47.0 1.0
CD2 B:HIS227 4.3 42.0 1.0
C B:ARG223 4.3 42.4 1.0
C5' 0:U2546 4.7 36.2 1.0
NH1 B:ARG223 4.8 45.3 1.0
N B:ARG223 4.8 43.0 1.0
CZ B:ARG223 4.9 45.5 1.0
O 0:HOH9056 4.9 16.5 1.0
O B:LYS222 4.9 44.6 1.0
ND1 B:HIS227 4.9 42.6 1.0

Chlorine binding site 3 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 3 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl8801

b:71.0
occ:1.00
 N J:ILE127 2.8 56.3 1.0
O 0:HOH5193 3.0 68.9 1.0
CG2 J:ILE127 3.2 55.8 1.0
N J:LYS128 3.2 53.6 1.0
OD1 J:ASN126 3.5 60.2 1.0
CA J:ASN126 3.5 57.4 1.0
O J:HOH8848 3.7 45.2 1.0
C J:ASN126 3.7 56.8 1.0
CA J:ILE127 3.7 55.5 1.0
O 0:HOH3904 3.9 77.5 1.0
CG E:PRO36 3.9 61.8 1.0
CB J:LYS128 3.9 50.8 1.0
C J:ILE127 3.9 54.4 1.0
CG J:LYS128 4.0 49.9 1.0
CB J:ILE127 4.0 55.9 1.0
CA J:LYS128 4.1 52.0 1.0
CB J:ASN126 4.1 58.4 1.0
O J:SER125 4.2 57.8 1.0
CG J:ASN126 4.2 60.3 1.0
N J:ASN126 4.6 57.4 1.0
CD J:LYS128 4.7 47.4 1.0
C J:SER125 4.8 58.5 1.0
O J:LYS128 4.8 51.3 1.0
CB E:PRO36 4.8 62.6 1.0
O J:ASN126 4.9 57.2 1.0
C J:LYS128 4.9 52.0 1.0

Chlorine binding site 4 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 4 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl8802

b:76.6
occ:1.00
 N J:LYS90 3.1 58.1 1.0
C J:PRO88 3.2 51.6 1.0
CA J:PRO88 3.3 51.4 1.0
CB J:LYS90 3.4 59.0 1.0
O J:PRO88 3.5 52.0 1.0
CA J:LYS90 3.6 60.4 1.0
CB J:PRO88 3.7 51.0 1.0
N J:LYS91 3.7 65.4 1.0
N J:HIS89 3.7 52.3 1.0
C J:LYS90 4.0 63.1 1.0
CG J:LYS91 4.1 71.5 1.0
CG J:LYS90 4.2 55.9 1.0
C J:HIS89 4.3 55.7 1.0
CA J:HIS89 4.5 53.8 1.0
N J:PRO88 4.7 51.8 1.0
CB J:LYS91 4.7 68.9 1.0
CA J:LYS91 4.7 68.0 1.0
CD J:LYS90 4.8 52.0 1.0
O J:LEU87 4.9 53.1 1.0
ND1 J:HIS89 4.9 49.3 1.0

Chlorine binding site 5 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 5 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl8821

b:66.2
occ:1.00
 O 0:HOH5751 2.7 36.7 1.0
N J:TYR69 3.4 59.5 1.0
N J:ASN65 3.4 57.2 1.0
CA J:GLY64 3.5 57.4 1.0
O J:ASN65 3.7 56.8 1.0
CA J:GLY68 3.7 58.5 1.0
C J:GLY64 3.9 58.1 1.0
C J:GLY68 4.0 58.6 1.0
O J:ILE63 4.3 55.3 1.0
CA J:TYR69 4.4 60.7 1.0
C J:TYR69 4.5 62.6 1.0
C J:ASN65 4.5 56.9 1.0
CA J:ASN65 4.5 56.3 1.0
O J:TYR69 4.5 63.1 1.0
CB J:TYR69 4.5 58.8 1.0
C5' 0:A2677 4.5 52.2 1.0
OP1 0:A2678 4.6 47.3 1.0
N J:GLY68 4.6 57.8 1.0
O3' 0:A2677 4.6 47.0 1.0
N J:GLY64 4.6 55.6 1.0
NA J:NA8538 4.7 49.7 1.0
C J:ILE63 4.9 55.5 1.0
C4' 0:A2677 5.0 48.8 1.0
N J:PHE70 5.0 64.4 1.0

Chlorine binding site 6 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 6 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cl8812

b:48.9
occ:1.00
 O K:HOH4058 2.7 47.8 1.0
NZ K:LYS14 2.9 34.8 1.0
C2 0:A2596 3.2 51.9 1.0
N3 0:A2596 3.3 52.0 1.0
OG K:SER33 3.4 49.9 1.0
CD K:LYS14 3.4 34.5 1.0
N2 0:G2582 3.6 43.7 1.0
O K:ILE32 3.7 45.2 1.0
CE K:LYS14 3.7 35.0 1.0
O 0:HOH7587 3.8 43.5 1.0
CG K:PRO45 3.9 41.8 1.0
CB K:SER33 4.2 47.9 1.0
CA K:SER33 4.2 46.3 1.0
C1' 0:U2597 4.2 52.1 1.0
N3 0:A2583 4.2 40.7 1.0
CB K:PRO45 4.3 42.1 1.0
N1 0:A2596 4.4 52.5 1.0
O K:HOH7169 4.6 0.0 1.0
C K:ILE32 4.7 46.0 1.0
CG K:LYS14 4.7 37.6 1.0
C4 0:A2596 4.7 52.6 1.0
O2' 0:U2597 4.7 53.7 1.0
O4' 0:U2597 4.7 51.4 1.0
C1' 0:A2583 4.8 41.0 1.0
O2 0:U2597 4.8 52.1 1.0
C2 0:A2583 4.8 41.5 1.0
C4 0:A2583 4.8 40.3 1.0
C2 0:G2582 4.8 42.0 1.0
N1 0:U2597 4.9 51.8 1.0
N K:SER33 4.9 45.9 1.0

Chlorine binding site 7 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 7 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cl8810

b:64.0
occ:1.00
 N L:ARG53 2.7 55.6 1.0
CA L:LYS52 3.4 52.8 1.0
C L:LYS52 3.5 54.3 1.0
CB L:ARG53 3.5 54.6 1.0
CA L:ARG53 3.6 56.7 1.0
CG L:ARG53 3.6 52.3 1.0
O L:ARG53 4.0 59.5 1.0
CB L:LYS52 4.0 52.2 1.0
NE2 L:GLN58 4.0 88.8 1.0
C5' 0:A693 4.2 54.8 1.0
C L:ARG53 4.3 59.1 1.0
CD L:GLN58 4.3 87.9 1.0
O L:PHE51 4.4 49.5 1.0
CD L:ARG53 4.4 50.1 1.0
N L:LYS52 4.6 51.5 1.0
OE1 L:GLN58 4.7 88.8 1.0
O3' 0:A693 4.7 58.4 1.0
CG L:LYS52 4.7 52.2 1.0
O L:LYS52 4.7 54.6 1.0
C4' 0:A693 4.8 55.8 1.0
OP1 0:A693 4.9 56.3 1.0
C L:PHE51 4.9 51.6 1.0
CG L:GLN58 5.0 87.2 1.0

Chlorine binding site 8 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 8 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
M:Cl8818

b:39.1
occ:1.00
 CG1 M:VAL159 3.0 36.8 1.0
OG M:SER106 3.0 34.0 1.0
N M:VAL114 3.2 35.3 1.0
N M:VAL159 3.5 38.2 1.0
CB M:VAL159 3.5 36.2 1.0
CA M:ARG113 3.8 35.4 1.0
O M:HOH8925 3.8 37.9 1.0
N M:ARG158 3.8 40.8 1.0
CG2 M:VAL114 3.9 34.6 1.0
CA M:ASP157 3.9 43.5 1.0
CB M:SER106 3.9 34.2 1.0
C M:ASP157 3.9 42.4 1.0
C M:ARG113 4.0 35.8 1.0
CB M:VAL114 4.0 34.7 1.0
CA M:VAL159 4.1 36.7 1.0
CG M:ARG158 4.2 40.2 1.0
CA M:VAL114 4.2 35.0 1.0
O M:LEU112 4.4 36.7 1.0
CB M:ARG113 4.4 35.0 1.0
N M:ASP157 4.4 42.1 1.0
C M:ARG158 4.5 39.9 1.0
NA M:NA8539 4.5 32.7 1.0
O M:ASP157 4.5 41.2 1.0
CA M:ARG158 4.6 40.4 1.0
CE1 M:PHE160 4.8 37.6 1.0
CG2 M:VAL159 4.8 33.9 1.0
N M:ARG113 4.9 35.6 1.0
CD1 M:PHE160 4.9 37.9 1.0
CG M:ARG113 5.0 36.0 1.0
CB M:ARG158 5.0 40.4 1.0
O M:VAL114 5.0 37.0 1.0

Chlorine binding site 9 out of 22 in 3ccr

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Chlorine binding site 9 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Cl8807

b:99.0
occ:1.00
 N N:LYS38 3.1 81.4 1.0
OD1 N:ASN107 3.2 70.1 1.0
CD N:ARG37 3.2 75.7 1.0
CB N:ARG37 3.5 76.1 1.0
CA N:ARG37 3.5 76.4 1.0
O N:HOH8814 3.6 52.7 1.0
C N:ARG37 3.8 79.0 1.0
O N:LYS38 3.8 87.0 1.0
NZ D:LYS146 3.9 82.0 1.0
CG N:ARG37 3.9 76.0 1.0
CD D:LYS146 4.1 80.1 1.0
CE D:LYS146 4.1 81.0 1.0
CA N:LYS38 4.1 84.1 1.0
C N:LYS38 4.2 86.0 1.0
CG N:ASN107 4.3 69.9 1.0
NE N:ARG37 4.4 74.8 1.0
CB N:LYS38 4.4 84.0 1.0
ND2 N:ASN107 4.7 69.4 1.0
O N:ARG37 4.9 79.9 1.0
O N:ALA36 4.9 68.5 1.0
N N:ARG37 4.9 72.3 1.0
CG N:LYS38 4.9 85.6 1.0

Chlorine binding site 10 out of 22 in 3ccr

Go back to Chlorine Binding Sites List in 3ccr
Chlorine binding site 10 out of 22 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488C. Density For Anisomycin Is Visible But Not Included in the Model. within 5.0Å range:
probe atom residue distance (Å) B Occ
O:Cl8808

b:87.4
occ:1.00
 ND2 O:ASN44 2.9 51.1 1.0
O 0:HOH7040 3.0 70.9 1.0
C8 0:G745 3.3 62.8 1.0
CB O:ASN44 3.4 50.2 1.0
O 0:HOH6830 3.5 33.8 1.0
N O:ASN44 3.5 50.1 1.0
CG O:ASN44 3.6 50.8 1.0
N7 0:G745 3.7 63.9 1.0
O 0:HOH7050 3.9 52.4 1.0
CA O:ASN44 4.1 49.9 1.0
O O:GLU42 4.2 54.0 1.0
NH2 O:ARG47 4.2 65.6 1.0
NE O:ARG47 4.4 63.1 1.0
C3' 0:G745 4.4 53.1 1.0
OP2 0:A746 4.5 47.9 1.0
C O:VAL43 4.5 51.8 1.0
N9 0:G745 4.6 62.8 1.0
CA O:VAL43 4.6 53.3 1.0
C2' 0:G745 4.6 55.3 1.0
CZ O:ARG47 4.7 64.5 1.0
O5' 0:G745 4.7 51.9 1.0
OD1 O:ASN44 4.8 51.9 1.0
OP2 0:G745 4.9 50.8 1.0
CB O:ARG47 4.9 58.9 1.0
C O:ASN44 4.9 49.8 1.0

Reference:

G.Blaha, G.Gurel, S.J.Schroeder, P.B.Moore, T.A.Steitz. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. J.Mol.Biol. V. 379 505 2008.
ISSN: ISSN 0022-2836
PubMed: 18455733
DOI: 10.1016/J.JMB.2008.03.075
Page generated: Sat Jul 20 17:12:36 2024

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