Chlorine in PDB 3drc: Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis

Enzymatic activity of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis

All present enzymatic activity of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis:
1.5.1.3;

Protein crystallography data

The structure of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis, PDB code: 3drc was solved by S.J.Oatley, J.Kraut, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	N/A / 1.90
*Space group*	P 6₁
*Cell size a, b, c (Å), α, β, γ (°)*	93.120, 93.120, 73.870, 90.00, 90.00, 120.00
*R / R_free (%)*	n/a / n/a

Other elements in 3drc:

The structure of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis (pdb code 3drc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis, PDB code: 3drc:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3drc

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Chlorine Binding Sites List in 3drc

Chlorine binding site 1 out of 2 in the Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl401 b:23.0 occ:1.00	O	A:HOH580	3.0	77.0	1.0
	O	A:HOH460	3.1	38.0	1.0
	N	A:GLY96	3.2	12.0	1.0
	N	A:THR46	3.3	11.0	1.0
	OG1	A:THR46	3.4	16.0	1.0
	N	A:HIS45	3.4	14.0	1.0
	CA	A:GLY43	3.5	17.0	1.0
	C	A:GLY43	3.5	19.0	1.0
	CB	A:HIS45	3.5	13.0	1.0
	O	A:HOH436	3.7	37.0	1.0
	CA	A:GLY96	3.7	11.0	1.0
	O	A:GLY43	3.9	16.0	1.0
	N	A:ARG44	3.9	14.0	1.0
	N	A:GLY43	3.9	18.0	1.0
	CA	A:HIS45	3.9	13.0	1.0
	CB	A:THR46	4.0	14.0	1.0
	C	A:GLY95	4.1	16.0	1.0
	O	A:HOH429	4.1	48.0	1.0
	C	A:HIS45	4.1	14.0	1.0
	ND1	A:HIS45	4.2	24.0	1.0
	CA	A:THR46	4.2	13.0	1.0
	O	A:GLY95	4.2	16.0	1.0
	CG	A:HIS45	4.3	18.0	1.0
	O	A:HOH461	4.4	38.0	1.0
	C	A:ARG44	4.4	16.0	1.0
	C	A:GLY96	4.6	18.0	1.0
	CA	A:ARG44	4.7	17.0	1.0
	O	A:HOH581	4.8	63.0	1.0
	CG2	A:VAL99	5.0	20.0	1.0

Chlorine binding site 2 out of 2 in 3drc

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Chlorine Binding Sites List in 3drc

Chlorine binding site 2 out of 2 in the Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Cl605 b:28.0 occ:1.00	O	B:HOH742	3.1	36.0	1.0
	N	B:THR46	3.2	24.0	1.0
	OG1	B:THR46	3.2	19.0	1.0
	N	B:GLY96	3.3	15.0	1.0
	CA	B:GLY43	3.4	22.0	1.0
	C	B:GLY43	3.6	19.0	1.0
	N	B:HIS45	3.6	22.0	1.0
	CB	B:HIS45	3.8	33.0	1.0
	O	B:GLY43	3.9	21.0	1.0
	CA	B:GLY96	3.9	16.0	1.0
	CB	B:THR46	3.9	21.0	1.0
	N	B:GLY43	3.9	16.0	1.0
	CA	B:HIS45	3.9	24.0	1.0
	C	B:HIS45	4.1	26.0	1.0
	N	B:ARG44	4.1	23.0	1.0
	C	B:GLY95	4.1	17.0	1.0
	CA	B:THR46	4.1	22.0	1.0
	O	B:GLY95	4.1	18.0	1.0
	O	B:HOH741	4.4	53.0	1.0
	CD2	B:HIS45	4.5	43.0	1.0
	C	B:ARG44	4.5	23.0	1.0
	CG	B:HIS45	4.6	42.0	1.0
	C	B:GLY96	4.8	16.0	1.0
	CG2	B:VAL99	4.8	20.0	1.0
	CA	B:ARG44	4.9	27.0	1.0
	O	B:HOH635	4.9	31.0	1.0
	O	B:HOH695	5.0	61.0	1.0

Reference:

M.S.Warren, K.A.Brown, M.F.Farnum, E.E.Howell, J.Kraut. Investigation of the Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase By Site-Directed Mutagenesis. Biochemistry V. 30 11092 1991.
ISSN: ISSN 0006-2960
PubMed: 1932031
DOI: 10.1021/BI00110A011

Page generated: Sat Jul 20 18:30:25 2024

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