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Atomistry » Chlorine » PDB 3dn8-3dyv » 3drp | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3dn8-3dyv » 3drp » |
Chlorine in PDB 3drp: Hiv Reverse Transcriptase in Complex with Inhibitor R8EEnzymatic activity of Hiv Reverse Transcriptase in Complex with Inhibitor R8E
All present enzymatic activity of Hiv Reverse Transcriptase in Complex with Inhibitor R8E:
2.7.7.49; 2.7.7.7; 3.1.26.4; Protein crystallography data
The structure of Hiv Reverse Transcriptase in Complex with Inhibitor R8E, PDB code: 3drp
was solved by
Y.Yan,
S.Prasad,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hiv Reverse Transcriptase in Complex with Inhibitor R8E
(pdb code 3drp). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Hiv Reverse Transcriptase in Complex with Inhibitor R8E, PDB code: 3drp: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 3drpGo back to Chlorine Binding Sites List in 3drp
Chlorine binding site 1 out
of 2 in the Hiv Reverse Transcriptase in Complex with Inhibitor R8E
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 3drpGo back to Chlorine Binding Sites List in 3drp
Chlorine binding site 2 out
of 2 in the Hiv Reverse Transcriptase in Complex with Inhibitor R8E
Mono view Stereo pair view
Reference:
T.J.Tucker,
J.T.Sisko,
R.M.Tynebor,
T.M.Williams,
P.J.Felock,
J.A.Flynn,
M.T.Lai,
Y.Liang,
G.Mcgaughey,
M.Liu,
M.Miller,
G.Moyer,
V.Munshi,
R.Perlow-Poehnelt,
S.Prasad,
J.C.Reid,
R.Sanchez,
M.Torrent,
J.P.Vacca,
B.L.Wan,
Y.Yan.
Discovery of 3-{5-[(6-Amino-1H-Pyrazolo[3,4-B]Pyridine-3-Yl) Methoxy]-2-Chlorophenoxy}-5-Chlorobenzonitrile (Mk-4965): A Potent, Orally Bioavailable Hiv-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency Against Key Mutant Viruses. J.Med.Chem. V. 51 6503 2008.
Page generated: Sat Dec 12 09:39:07 2020
ISSN: ISSN 0022-2623 PubMed: 18826204 DOI: 10.1021/JM800856C |
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