Chlorine in PDB 3du7: Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex

The structure of Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex, PDB code: 3du7 was solved by A.Cormier, M.Marchand, R.B.Ravelli, M.Knossow, B.Gigant, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 4.10
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	327.126, 327.126, 53.672, 90.00, 90.00, 120.00
R / Rfree (%)	21.5 / 26.5

The structure of Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Chlorine atom in the Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex (pdb code 3du7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex, PDB code: 3du7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl800 b:99.0 occ:1.00 CL1 B:HOS800 0.0 99.0 1.0 C11 B:HOS800 1.7 99.0 1.0 C12 B:HOS800 2.6 99.0 1.0 C10 B:HOS800 2.7 99.0 1.0 O5 B:HOS800 2.9 99.0 1.0 CG2 B:THR221 3.2 95.9 1.0 OD1 C:ASN329 3.4 95.9 1.0 O2 B:HOS800 3.7 99.0 1.0 CD B:PRO222 3.8 95.9 1.0 C1 B:HOS800 3.9 99.0 1.0 CB B:THR221 4.0 95.9 1.0 C9 B:HOS800 4.1 99.0 1.0 CA B:THR221 4.1 95.9 1.0 N B:PRO222 4.2 95.9 1.0 CG C:ASN329 4.2 95.9 1.0 C B:THR221 4.2 95.9 1.0 O B:PRO222 4.2 95.9 1.0 C13 B:HOS800 4.5 99.0 1.0 C4 B:HOS800 4.6 99.0 1.0 CG2 B:VAL177 4.8 95.9 1.0 ND2 C:ASN329 4.8 95.9 1.0 CE2 B:TYR210 4.8 95.9 1.0 C3 B:HOS800 4.9 99.0 1.0 O1 B:HOS800 4.9 99.0 1.0 O B:THR221 5.0 95.9 1.0 CG B:PRO222 5.0 95.9 1.0

Chlorine binding site 2 out of 2 in the Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Tubulin-Colchicine-Phomopsin A: Stathmin-Like Domain Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl801 b:99.0 occ:1.00 CL1 D:HOS801 0.0 99.0 1.0 C11 D:HOS801 1.7 99.0 1.0 C12 D:HOS801 2.7 99.0 1.0 C10 D:HOS801 2.8 99.0 1.0 O5 D:HOS801 2.9 99.0 1.0 CE2 D:TYR210 3.5 95.9 1.0 CD D:PRO222 3.5 95.9 1.0 C1 D:HOS801 4.0 99.0 1.0 O2 D:HOS801 4.0 99.0 1.0 CG2 D:THR221 4.0 95.9 1.0 C9 D:HOS801 4.0 99.0 1.0 CZ D:TYR210 4.1 95.9 1.0 CG2 D:VAL177 4.1 95.9 1.0 OH D:TYR210 4.2 95.9 1.0 CD2 D:TYR210 4.2 95.9 1.0 N D:PRO222 4.4 95.9 1.0 C13 D:HOS801 4.5 99.0 1.0 CA D:THR221 4.5 95.9 1.0 CG D:PRO222 4.5 95.9 1.0 O D:PRO222 4.7 95.9 1.0 C D:THR221 4.8 95.9 1.0 CB D:THR221 4.8 95.9 1.0 C4 D:HOS801 4.9 99.0 1.0

A.Cormier, M.Marchand, R.B.Ravelli, M.Knossow, B.Gigant. Structural Insight Into the Inhibition of Tubulin By Vinca Domain Peptide Ligands Embo Rep. V. 9 1101 2008.
ISSN: ISSN 1469-221X
PubMed: 18787557
DOI: 10.1038/EMBOR.2008.171