Chlorine in PDB 3e6y: Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A

The structure of Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A, PDB code: 3e6y was solved by C.Ottmann, M.Weyand, A.Wittinghofer, C.Oecking, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.95 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	41.800, 141.900, 51.400, 90.00, 114.10, 90.00
R / Rfree (%)	19.5 / 28.5

The binding sites of Chlorine atom in the Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A (pdb code 3e6y). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A, PDB code: 3e6y:

Chlorine binding site 1 out of 1 in the Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of 14-3-3 in Complex with the Differentiation-Inducing Agent Cotylenin A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl262 b:43.2 occ:1.00 O A:HOH270 2.8 18.9 1.0 CG A:ARG63 3.1 19.6 1.0 OE1 A:GLU140 3.3 24.9 1.0 CA A:ARG63 3.7 16.8 1.0 CD1 A:LEU99 3.9 21.0 1.0 CE3 A:TRP66 4.0 13.4 1.0 CB A:GLU140 4.0 20.4 1.0 CB A:ARG63 4.0 17.0 1.0 CD2 A:TRP66 4.1 13.6 1.0 CB A:TRP66 4.1 14.6 1.0 CG A:TRP66 4.2 14.9 1.0 CD A:ARG63 4.2 18.0 1.0 CD A:GLU140 4.3 20.0 1.0 CD1 A:PHE141 4.3 16.8 1.0 CD2 A:LEU99 4.3 16.9 1.0 O A:ARG63 4.4 16.0 1.0 C A:ARG63 4.6 16.1 1.0 N A:ARG63 4.6 14.8 1.0 CG A:GLU140 4.6 19.9 1.0 CZ3 A:TRP66 4.8 9.5 1.0 CG A:LEU99 4.8 19.6 1.0 O A:TYR137 4.8 18.2 1.0 CB A:PHE141 4.9 19.9 1.0 CE2 A:TRP66 4.9 12.1 1.0 CG A:PHE141 5.0 18.5 1.0

C.Ottmann, M.Weyand, T.Sassa, T.Inoue, N.Kato, A.Wittinghofer, C.Oecking. A Structural Rationale For Selective Stabilization of Anti-Tumor Interactions of 14-3-3 Proteins By Cotylenin A J.Mol.Biol. V. 386 913 2009.
ISSN: ISSN 0022-2836
PubMed: 19244612