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Chlorine in PDB 3ex6: D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct

Enzymatic activity of D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct

All present enzymatic activity of D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct:
4.1.1.23;

Protein crystallography data

The structure of D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct, PDB code: 3ex6 was solved by D.Heinrich, U.Diederichsen, M.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.68 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 69.490, 61.580, 70.720, 90.00, 113.43, 90.00
R / Rfree (%) 16.7 / 19.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct (pdb code 3ex6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct, PDB code: 3ex6:

Chlorine binding site 1 out of 1 in 3ex6

Go back to Chlorine Binding Sites List in 3ex6
Chlorine binding site 1 out of 1 in the D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of D312N Mutant of Human Orotidyl-5'-Monophosphate Decarboxylase in Complex with 6-Azido-Ump, Covalent Adduct within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl483

b:29.0
occ:1.00
 O A:HOH739 2.7 23.3 1.0
NZ A:LYS314 2.8 12.9 1.0
O A:HOH738 3.0 17.1 1.0
O A:HOH746 3.1 13.2 1.0
CE A:LYS314 3.5 14.1 1.0
CG A:PRO417 3.6 8.8 1.0
CB A:PRO417 3.7 10.1 1.0
O B:HOH712 3.8 26.6 1.0
NZ A:LYS281 4.0 13.0 1.0
OD1 B:ASP317 4.1 17.7 1.0
O A:HOH737 4.2 16.9 1.0
O A:HOH742 4.6 26.4 1.0
O A:HOH740 4.6 27.6 1.0
OD1 A:ASN312 4.7 9.9 1.0
OG A:SER372 4.8 19.7 1.0
CG2 B:ILE318 4.9 17.1 1.0
CD A:LYS314 4.9 12.8 1.0
CD A:PRO417 5.0 8.8 1.0

Reference:

D.Heinrich, U.Diederichsen, M.G.Rudolph. LYS314 Is A Nucleophile in Non-Classical Reactions of Orotidine-5'-Monophosphate Decarboxylase Chemistry V. 15 6619 2009.
ISSN: ISSN 0947-6539
PubMed: 19472232
DOI: 10.1002/CHEM.200900397
Page generated: Sat Dec 12 09:40:52 2020

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