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Atomistry » Chlorine » PDB 3f68-3fed » 3f82 » |
Chlorine in PDB 3f82: Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- CarboxamideEnzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide
All present enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide, PDB code: 3f82
was solved by
J.Sack,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3f82:
The structure of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide
(pdb code 3f82). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide, PDB code: 3f82: Chlorine binding site 1 out of 1 in 3f82Go back to Chlorine Binding Sites List in 3f82
Chlorine binding site 1 out
of 1 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with N- (4-(2-Amino-3-Chloropyridin-4-Yloxy)-3-Fluorophenyl)-4- Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1,2-Dihydropyridine-3- Carboxamide
Mono view Stereo pair view
Reference:
G.M.Schroeder,
Y.An,
Z.W.Cai,
X.T.Chen,
C.Clark,
L.A.Cornelius,
J.Dai,
J.Gullo-Brown,
A.Gupta,
B.Henley,
J.T.Hunt,
R.Jeyaseelan,
A.Kamath,
K.Kim,
J.Lippy,
L.J.Lombardo,
V.Manne,
S.Oppenheimer,
J.S.Sack,
R.J.Schmidt,
G.Shen,
K.Stefanski,
J.S.Tokarski,
G.L.Trainor,
B.S.Wautlet,
D.Wei,
D.K.Williams,
Y.Zhang,
Y.Zhang,
J.Fargnoli,
R.M.Borzilleri.
Discovery of N-(4-(2-Amino-3-Chloropyridin-4-Yloxy)-3- Fluorophenyl)-4-Ethoxy-1-(4-Fluorophenyl)-2-Oxo-1, 2-Dihydropyridine-3-Carboxamide (Bms-777607), A Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily J.Med.Chem. V. 52 1251 2009.
Page generated: Sat Dec 12 09:41:22 2020
ISSN: ISSN 0022-2623 PubMed: 19260711 DOI: 10.1021/JM801586S |
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