Chlorine in PDB 3frq: Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin

The structure of Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin, PDB code: 3frq was solved by J.Zheng, V.Sagar, A.Smolinsky, C.Bourke, N.Laronde-Leblanc, T.A.Cropp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	67.27 / 1.76
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.294, 61.201, 134.642, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 22.1

The binding sites of Chlorine atom in the Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin (pdb code 3frq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin, PDB code: 3frq:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl198 b:35.0 occ:1.00 O8 A:ERY195 3.0 27.1 1.0 O A:HOH224 3.1 32.7 1.0 N A:ASN94 3.1 31.4 1.0 CB A:ASN94 3.6 34.3 1.0 C23 A:ERY195 3.6 25.5 1.0 O A:HOH227 3.7 35.7 1.0 C31 A:ERY195 3.9 20.8 1.0 CA A:ASN94 4.0 33.4 1.0 CA A:MET93 4.0 28.5 1.0 C A:MET93 4.1 29.5 1.0 O A:SER92 4.1 28.4 1.0 C28 A:ERY195 4.2 30.5 1.0 O7 A:ERY195 4.3 18.7 1.0 O A:ASN94 4.5 32.2 1.0 N1 A:ERY195 4.6 31.9 1.0 C22 A:ERY195 4.6 21.8 1.0 NZ A:LYS21 4.7 40.2 1.0 C24 A:ERY195 4.8 27.0 1.0 O5 A:ERY195 4.8 20.3 1.0 C A:ASN94 4.8 34.1 1.0 CE A:LYS21 4.8 35.6 1.0 CB A:MET93 4.9 28.1 1.0 C20 A:ERY195 4.9 24.0 1.0 C A:SER92 4.9 28.4 1.0 O A:HOH300 5.0 28.8 1.0

Chlorine binding site 2 out of 2 in the Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Macrolide Biosensor Protein, Mphr(A), with Erythromcyin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl200 b:38.9 occ:1.00 O8 B:ERY195 2.9 33.5 1.0 O B:HOH309 3.0 33.6 1.0 N B:ASN94 3.2 26.7 1.0 C23 B:ERY195 3.6 31.1 1.0 CB B:ASN94 3.7 28.0 1.0 C31 B:ERY195 3.9 23.1 1.0 CA B:MET93 4.0 25.9 1.0 CA B:ASN94 4.1 27.9 1.0 O B:SER92 4.1 27.6 1.0 C B:MET93 4.1 26.3 1.0 N1 B:ERY195 4.1 39.0 1.0 O7 B:ERY195 4.4 25.0 1.0 O B:ASN94 4.5 27.5 1.0 C24 B:ERY195 4.6 34.6 1.0 C22 B:ERY195 4.6 28.3 1.0 CB B:MET93 4.7 25.8 1.0 C28 B:ERY195 4.8 40.3 1.0 C B:ASN94 4.8 28.6 1.0 CE B:LYS21 4.8 41.5 1.0 C B:SER92 4.9 26.8 1.0 N B:MET93 4.9 25.2 1.0 C29 B:ERY195 5.0 44.0 1.0 O5 B:ERY195 5.0 25.7 1.0

J.Zheng, V.Sagar, A.Smolinsky, C.Bourke, N.Laronde-Leblanc, T.A.Cropp. Structure and Function of the Macrolide Biosensor Protein, Mphr(A), with and Without Erythromycin J.Mol.Biol. V. 387 1250 2009.
ISSN: ISSN 0022-2836
PubMed: 19265703
DOI: 10.1016/J.JMB.2009.02.058