|
Atomistry » Chlorine » PDB 3fr1-3fzn » 3fsf | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3fr1-3fzn » 3fsf » |
Chlorine in PDB 3fsf: P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-OneEnzymatic activity of P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One
All present enzymatic activity of P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One:
2.7.11.24; Protein crystallography data
The structure of P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One, PDB code: 3fsf
was solved by
A.Kuglstatter,
J.Bertrand,
B.Lovejoy,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One
(pdb code 3fsf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One, PDB code: 3fsf: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 3fsfGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 3fsfGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the P38 Kinase Crystal Structure in Complex with 3-(2,6- Dichloro-Phenyl)-7-[4-(2-Diethylamino-Ethoxy)-Phenylamino]- 1-Methyl-3,4-Dihydro-1H-Pyrimido[4,5-D]Pyrimidin-2-One
![]() Mono view ![]() Stereo pair view
Reference:
M.Soth,
A.Kuglstatter,
D.Goldstein.
The Discovery of Pamapimod and R1487 As Orally Bioavailable and Highly Selective Inhibitors of P38 Map Kinase To Be Published.
Page generated: Sat Jul 20 19:35:25 2024
|
Last articlesZn in 9J0NZn in 9J0O Zn in 9J0P Zn in 9FJX Zn in 9EKB Zn in 9C0F Zn in 9CAH Zn in 9CH0 Zn in 9CH3 Zn in 9CH1 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |