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Chlorine in PDB 3fue: Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin
Enzymatic activity of Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin
All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin:
3.3.2.6;
3.3.2.6;
Protein crystallography data
The structure of Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin, PDB code: 3fue
was solved by
D.R.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.38 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 78.084, 86.936, 99.111, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.1 / 25 |
Other elements in 3fue:
The structure of Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin also contains other interesting chemical elements:
| Ytterbium | (Yb) | 3 atoms |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin
(pdb code 3fue). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin, PDB code: 3fue:
In total only one binding site of Chlorine was determined in the Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin, PDB code: 3fue:
Chlorine binding site 1 out of 1 in 3fue
Go back to
Chlorine Binding Sites List in 3fue
Chlorine binding site 1 out
of 1 in the Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Leukotriene A4 Hydrolase in Complex with Fragment 5- Chloroindole and Bestatin within 5.0Å range:
|
Reference:
D.R.Davies,
B.Mamat,
O.T.Magnusson,
J.Christensen,
M.H.Haraldsson,
R.Mishra,
B.Pease,
E.Hansen,
J.Singh,
D.Zembower,
H.Kim,
A.S.Kiselyov,
A.B.Burgin,
M.E.Gurney,
L.J.Stewart.
Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
Page generated: Sat Dec 12 09:42:34 2020
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
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