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Chlorine in PDB 3h1x: Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site

Enzymatic activity of Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site

All present enzymatic activity of Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site:
3.1.1.4;

Protein crystallography data

The structure of Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site, PDB code: 3h1x was solved by N.Singh, R.Prem Kumar, S.Sharma, P.Kaur, T.P.Singh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 51.99 / 1.40
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 51.660, 51.660, 48.003, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 20.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site (pdb code 3h1x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site, PDB code: 3h1x:

Chlorine binding site 1 out of 1 in 3h1x

Go back to Chlorine Binding Sites List in 3h1x
Chlorine binding site 1 out of 1 in the Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand Binding Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:45.9
occ:0.77
 CL A:IMN301 0.0 45.9 0.8
C13 A:IMN301 1.8 40.5 0.8
O A:PRO56 2.4 24.2 1.0
C12 A:IMN301 2.7 39.2 0.8
C14 A:IMN301 2.8 38.7 0.8
C A:PRO56 3.5 24.3 1.0
C11 A:IMN301 4.0 37.7 0.8
CA A:PRO56 4.1 23.8 1.0
C15 A:IMN301 4.1 37.5 0.8
O A:CYS61 4.4 20.3 1.0
C10 A:IMN301 4.6 36.9 0.8
N A:ASP59 4.7 21.9 1.0
CB A:PRO56 4.8 24.3 1.0
CA A:ASP59 4.9 21.1 1.0

Reference:

N.Singh, R.P.Kumar, S.Kumar, S.Sharma, R.Mir, P.Kaur, A.Srinivasan, T.P.Singh. Simultaneous Inhibition of Anti-Coagulation and Inflammation: Crystal Structure of Phospholipase A2 Complexed with Indomethacin at 1.4 A Resolution Reveals the Presence of the New Common Ligand-Binding Site J.Mol.Recognit. V. 22 437 2009.
ISSN: ISSN 0952-3499
PubMed: 19462410
DOI: 10.1002/JMR.960
Page generated: Sat Jul 20 20:36:40 2024

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