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Atomistry » Chlorine » PDB 3hwl-3i60 » 3i60 » |
Chlorine in PDB 3i60: Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- CarboxamideEnzymatic activity of Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide
All present enzymatic activity of Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide:
2.7.11.24; Protein crystallography data
The structure of Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide, PDB code: 3i60
was solved by
M.D.Jacobs,
X.Xie,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide
(pdb code 3i60). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide, PDB code: 3i60: Chlorine binding site 1 out of 1 in 3i60Go back to Chlorine Binding Sites List in 3i60
Chlorine binding site 1 out
of 1 in the Crystal Structure of ERK2 Bound to (S)-4-(2-(2-Chlorophenylamino)-5- Methylpyrimidin-4-Yl)-N-(2-Hydroxy-1-Phenylethyl)-1H-Pyrrole-2- Carboxamide
Mono view Stereo pair view
Reference:
A.M.Aronov,
Q.Tang,
G.Martinez-Botella,
G.W.Bemis,
J.Cao,
G.Chen,
N.P.Ewing,
P.J.Ford,
U.A.Germann,
J.Green,
M.R.Hale,
M.Jacobs,
J.W.Janetka,
F.Maltais,
W.Markland,
M.N.Namchuk,
S.Nanthakumar,
S.Poondru,
J.Straub,
E.Ter Haar,
X.Xie.
Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (Erk) Using Conformational Control. J.Med.Chem. V. 52 6362 2009.
Page generated: Sat Dec 12 09:47:10 2020
ISSN: ISSN 0022-2623 PubMed: 19827834 DOI: 10.1021/JM900630Q |
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