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Chlorine in PDB 3ibn: The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor
Enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor
All present enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor, PDB code: 3ibn
was solved by
V.Alterio,
G.De Simone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.20 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 41.990, 41.340, 71.850, 90.00, 104.25, 90.00 |
| R / Rfree (%) | 18.7 / 22.3 |
Other elements in 3ibn:
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor also contains other interesting chemical elements:
| Mercury | (Hg) | 1 atom |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor
(pdb code 3ibn). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor, PDB code: 3ibn:
In total only one binding site of Chlorine was determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor, PDB code: 3ibn:
Chlorine binding site 1 out of 1 in 3ibn
Go back to
Chlorine Binding Sites List in 3ibn
Chlorine binding site 1 out
of 1 in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with An Aliphatic Bis-Sulfamate Inhibitor within 5.0Å range:
|
Reference:
R.M.Vitale,
V.Alterio,
A.Innocenti,
J.-Y.Winum,
S.M.Monti,
G.De Simone,
C.T.Supuran.
Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-Sulfamate Adducts with Isozymes II and IX As A Platform For Designing Tight-Binding, More Isoform-Selective Inhibitors J.Med.Chem. V. 52 5990 2009.
ISSN: ISSN 0022-2623
PubMed: 19731956
DOI: 10.1021/JM900641R
Page generated: Sat Jul 20 21:27:26 2024
ISSN: ISSN 0022-2623
PubMed: 19731956
DOI: 10.1021/JM900641R
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