Chlorine in PDB 3jsd: Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3jsd was solved by M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	17.37 / 2.50
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	80.843, 80.843, 38.842, 90.00, 90.00, 120.00
R / Rfree (%)	20.6 / 27.4

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus (pdb code 3jsd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3jsd:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl32 b:5.3 occ:0.33 ZN B:ZN31 2.2 2.4 0.3 NE2 B:HIS10 3.4 25.8 1.0 CD2 B:HIS10 3.9 25.8 1.0 CE1 B:HIS10 4.6 24.6 1.0

Chlorine binding site 2 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl32 b:1.0 occ:0.33 ZN D:ZN31 2.3 1.5 0.3 NE2 D:HIS10 3.4 29.7 1.0 CD2 D:HIS10 3.8 31.6 1.0 CB D:LEU6 4.0 37.9 1.0 CD1 D:LEU6 4.3 39.0 1.0 CE1 D:HIS10 4.6 28.9 1.0 O D:LEU6 4.6 38.3 1.0 CG D:LEU6 4.7 40.1 1.0 C D:LEU6 4.8 39.6 1.0 CA D:LEU6 4.9 39.9 1.0

M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson. Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus To Be Published.