Atomistry » Chlorine » PDB 3jpy-3k1n » 3jw2
Atomistry »
  Chlorine »
    PDB 3jpy-3k1n »
      3jw2 »

Chlorine in PDB 3jw2: Hiv-1 Protease Mutant G86S with Darunavir

Enzymatic activity of Hiv-1 Protease Mutant G86S with Darunavir

All present enzymatic activity of Hiv-1 Protease Mutant G86S with Darunavir:
3.4.23.16;

Protein crystallography data

The structure of Hiv-1 Protease Mutant G86S with Darunavir, PDB code: 3jw2 was solved by Y.Tie, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.80
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 58.355, 86.145, 46.369, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 28.2

Other elements in 3jw2:

The structure of Hiv-1 Protease Mutant G86S with Darunavir also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hiv-1 Protease Mutant G86S with Darunavir (pdb code 3jw2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hiv-1 Protease Mutant G86S with Darunavir, PDB code: 3jw2:

Chlorine binding site 1 out of 1 in 3jw2

Go back to Chlorine Binding Sites List in 3jw2
Chlorine binding site 1 out of 1 in the Hiv-1 Protease Mutant G86S with Darunavir


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hiv-1 Protease Mutant G86S with Darunavir within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl502

b:21.4
occ:1.00
NZ B:LYS155 3.0 31.9 0.6
O B:HOH1104 3.1 25.7 1.0
NZ B:LYS155 3.3 23.1 0.4
CD B:LYS155 3.8 27.0 0.4
CB B:PRO144 3.9 17.5 1.0
CH2 B:TRP142 3.9 14.3 1.0
CZ3 B:TRP142 4.0 14.5 1.0
CE B:LYS155 4.1 27.2 0.4
CE B:LYS155 4.2 28.2 0.6
CG B:LYS155 4.2 27.7 0.6
O B:HOH1111 4.5 31.4 0.5
CA B:PRO144 4.6 16.1 1.0
CD B:LYS155 4.8 29.9 0.6
O B:HOH1054 5.0 54.5 1.0

Reference:

R.Ishima, Q.Gong, Y.Tie, I.T.Weber, J.M.Louis. Highly Conserved Glycine 86 and Arginine 87 Residues Contribute Differently to the Structure and Activity of the Mature Hiv-1 Protease Proteins V. 78 1015 2009.
ISSN: ISSN 0887-3585
PubMed: 19899162
DOI: 10.1002/PROT.22625
Page generated: Sat Dec 12 09:49:45 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy