Atomistry » Chlorine » PDB 3l29-3lc2 » 3l3n
Atomistry »
  Chlorine »
    PDB 3l29-3lc2 »
      3l3n »

Chlorine in PDB 3l3n: Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw

Enzymatic activity of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw

All present enzymatic activity of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw:
3.4.15.1;

Protein crystallography data

The structure of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw, PDB code: 3l3n was solved by J.M.Watermeyer, W.L.Kroger, H.G.O'neil, B.T.Sewell, E.D.Sturrock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.00 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.383, 84.789, 133.958, 90.00, 90.00, 90.00
R / Rfree (%) 22.6 / 26.6

Other elements in 3l3n:

The structure of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw (pdb code 3l3n). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw, PDB code: 3l3n:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3l3n

Go back to Chlorine Binding Sites List in 3l3n
Chlorine binding site 1 out of 2 in the Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl702

b:27.9
occ:1.00
NE A:ARG186 3.1 16.5 1.0
NH1 A:ARG186 3.2 16.2 1.0
NH1 A:ARG489 3.2 19.8 1.0
NE1 A:TRP485 3.3 20.2 1.0
CZ A:ARG186 3.6 15.2 1.0
CZ2 A:TRP486 3.7 18.4 1.0
O A:HOH1016 3.7 16.9 1.0
NE A:ARG489 3.7 20.2 1.0
CZ A:ARG489 3.7 20.9 1.0
CB A:ASP507 3.9 23.4 1.0
CE2 A:TRP485 4.1 19.4 1.0
CH2 A:TRP486 4.1 20.1 1.0
CZ2 A:TRP485 4.1 21.6 1.0
CD A:ARG186 4.2 16.1 1.0
CD1 A:TRP485 4.4 20.1 1.0
CE2 A:TRP486 4.4 19.3 1.0
CZ2 A:TRP182 4.5 15.1 1.0
O A:ASP507 4.5 20.4 1.0
O A:HOH1028 4.7 22.4 1.0
CG A:ASP507 4.7 24.3 1.0
C A:ASP507 4.8 21.0 1.0
NH2 A:ARG489 4.8 20.4 1.0
CD A:ARG489 4.9 23.6 1.0
NE1 A:TRP486 4.9 20.0 1.0
CA A:ASP507 4.9 21.7 1.0
NH2 A:ARG186 4.9 13.8 1.0

Chlorine binding site 2 out of 2 in 3l3n

Go back to Chlorine Binding Sites List in 3l3n
Chlorine binding site 2 out of 2 in the Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Testis Ace Co-Crystal Structure with Novel Inhibitor Lisw within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl703

b:19.7
occ:1.00
OH A:TYR224 2.9 22.3 1.0
O A:HOH1001 3.0 14.8 1.0
NE A:ARG522 3.3 19.4 1.0
CE1 A:TYR224 3.5 21.3 1.0
CG2 A:ILE521 3.5 16.4 1.0
CB A:PRO519 3.6 16.9 1.0
CB A:ARG522 3.6 18.2 1.0
N A:ARG522 3.6 17.1 1.0
CZ A:TYR224 3.6 21.6 1.0
NH2 A:ARG522 3.7 22.2 1.0
CE A:MET223 3.7 31.8 1.0
CB A:PRO407 3.7 17.7 1.0
CZ A:ARG522 3.9 21.4 1.0
CG A:PRO407 4.0 18.9 1.0
CA A:ARG522 4.0 18.5 1.0
CG A:ARG522 4.1 18.8 1.0
CD A:ARG522 4.3 19.6 1.0
C A:ILE521 4.5 17.0 1.0
CG A:PRO519 4.6 18.0 1.0
N A:ILE521 4.6 15.4 1.0
C A:PRO519 4.6 17.9 1.0
O A:HOH1031 4.7 15.0 1.0
SD A:MET223 4.7 31.2 1.0
CA A:PRO519 4.7 17.8 1.0
CB A:ILE521 4.8 17.0 1.0
O A:PRO519 4.8 18.9 1.0
CD1 A:TYR224 4.8 20.7 1.0
CA A:ILE521 4.8 16.7 1.0
CD A:PRO407 4.8 18.7 1.0
CE2 A:TYR224 4.9 21.7 1.0
N A:TYR520 5.0 17.9 1.0

Reference:

J.M.Watermeyer, W.L.Kroger, H.G.O'neill, B.T.Sewell, E.D.Sturrock. Characterization of Domain-Selective Inhibitor Binding in Angiotensin-Converting Enzyme Using A Novel Derivative of Lisinopril. Biochem.J. V. 428 67 2010.
ISSN: ISSN 0264-6021
PubMed: 20233165
DOI: 10.1042/BJ20100056
Page generated: Sat Dec 12 09:52:24 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy