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Chlorine in PDB 3maa: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration, PDB code: 3maa was solved by T.-C.Mou, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 3.00
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.744, 133.722, 70.992, 90.00, 90.00, 90.00
R / Rfree (%) 23.9 / 30.9

Other elements in 3maa:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration (pdb code 3maa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration, PDB code: 3maa:

Chlorine binding site 1 out of 1 in 3maa

Go back to Chlorine Binding Sites List in 3maa
Chlorine binding site 1 out of 1 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl397

b:50.8
occ:1.00
 O C:HOH398 2.6 27.2 1.0
N C:ALA249 3.2 17.1 1.0
CB C:ALA249 3.4 17.1 1.0
CB C:ALA48 3.5 24.3 1.0
CA C:ALA249 3.8 17.1 1.0
CB C:ALA269 3.9 22.0 1.0
C C:VAL248 4.2 17.1 1.0
O C:HOH400 4.3 34.4 1.0
CA C:SER51 4.3 19.8 1.0
CB C:SER51 4.3 23.1 1.0
CA C:VAL248 4.3 17.1 1.0
O C:GLY49 4.4 23.1 1.0
O C:ARG265 4.4 24.5 1.0
O C:ALA249 4.5 17.1 1.0
C C:ALA249 4.5 17.1 1.0
CA C:ALA48 4.7 22.6 1.0
N C:SER51 4.8 21.9 1.0
CG2 C:VAL248 4.8 17.1 1.0
CG1 C:VAL248 4.8 17.1 1.0
N C:ALA48 4.9 21.0 1.0
C C:ARG265 4.9 21.9 1.0
CB C:VAL248 4.9 17.1 1.0

Reference:

T.C.Mou, N.Masada, D.M.Cooper, S.R.Sprang. Structural Basis For Inhibition of Mammalian Adenylyl Cyclase By Calcium. Biochemistry V. 48 3387 2009.
ISSN: ISSN 0006-2960
PubMed: 19243146
DOI: 10.1021/BI802122K
Page generated: Fri Jul 11 07:48:40 2025

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