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Chlorine in PDB 3mmf: Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor
Enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor, PDB code: 3mmf
was solved by
B.S.Avvaru,
J.Wagner,
A.H.Robbins,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 23.84 / 1.50 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.336, 41.242, 72.050, 90.00, 104.31, 90.00 |
| R / Rfree (%) | 15.9 / 18.2 |
Other elements in 3mmf:
The structure of Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor
(pdb code 3mmf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor, PDB code: 3mmf:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor, PDB code: 3mmf:
Chlorine binding site 1 out of 1 in 3mmf
Go back to
Chlorine Binding Sites List in 3mmf
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Carbonic Anhydrase II in Complex with A 1, 3,5-Triazine-Substituted Benzenesulfonamide Inhibitor within 5.0Å range:
|
Reference:
F.Carta,
V.Garaj,
A.Maresca,
J.Wagner,
B.S.Avvaru,
A.H.Robbins,
A.Scozzafava,
R.Mckenna,
C.T.Supuran.
Sulfonamides Incorporating 1,3,5-Triazine Moieties Selectively and Potently Inhibit Carbonic Anhydrase Transmembrane Isoforms IX, XII and Xiv Over Cytosolic Isoforms I and II: Solution and X-Ray Crystallographic Studies. Bioorg.Med.Chem. V. 19 3105 2011.
ISSN: ISSN 0968-0896
PubMed: 21515057
DOI: 10.1016/J.BMC.2011.04.005
Page generated: Sat Dec 12 09:55:14 2020
ISSN: ISSN 0968-0896
PubMed: 21515057
DOI: 10.1016/J.BMC.2011.04.005
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