Atomistry » Chlorine » PDB 3n4e-3nb5 » 3n9j
Atomistry »
  Chlorine »
    PDB 3n4e-3nb5 »
      3n9j »

Chlorine in PDB 3n9j: Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin

Enzymatic activity of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin

All present enzymatic activity of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin:
2.5.1.18;

Protein crystallography data

The structure of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin, PDB code: 3n9j was solved by L.J.Parker, M.W.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.28 / 1.85
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 76.806, 89.994, 68.870, 90.00, 98.24, 90.00
R / Rfree (%) 17.8 / 21.8

Other elements in 3n9j:

The structure of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin also contains other interesting chemical elements:

Platinum (Pt) 1 atom
Calcium (Ca) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin (pdb code 3n9j). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin, PDB code: 3n9j:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 3n9j

Go back to Chlorine Binding Sites List in 3n9j
Chlorine binding site 1 out of 5 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl210

b:22.4
occ:0.50
 CL1 A:EAA210 0.0 22.4 0.5
C2 A:EAA210 1.8 23.2 0.5
C3 A:EAA210 2.8 23.1 0.5
C1 A:EAA210 2.8 23.7 0.5
OH A:TYR7 2.9 15.7 1.0
O A:HOH374 3.0 24.7 1.0
O2 A:EAA210 3.0 24.1 0.5
CL2 A:EAA210 3.2 24.0 0.5
O A:HOH297 3.6 22.3 1.0
O A:HOH304 3.6 19.4 1.0
CZ A:TYR7 3.7 16.6 1.0
OH A:TYR108 3.7 26.8 1.0
CG2 A:VAL10 4.0 19.0 1.0
C6 A:EAA210 4.1 24.1 0.5
C4 A:EAA210 4.1 24.6 0.5
CD2 A:PHE8 4.2 17.7 1.0
CE1 A:TYR7 4.3 16.4 1.0
C12 A:EAA210 4.4 21.8 0.5
OXT A:EAA210 4.4 21.2 0.5
CE2 A:TYR7 4.5 15.2 1.0
C5 A:EAA210 4.6 23.4 0.5
CE2 A:PHE8 4.6 20.1 1.0
CZ A:TYR108 4.6 27.3 1.0
CA A:GLY12 4.9 14.1 1.0
C13 A:EAA210 4.9 21.4 0.5

Chlorine binding site 2 out of 5 in 3n9j

Go back to Chlorine Binding Sites List in 3n9j
Chlorine binding site 2 out of 5 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl210

b:24.0
occ:0.50
 CL2 A:EAA210 0.0 24.0 0.5
C3 A:EAA210 1.8 23.1 0.5
C2 A:EAA210 2.8 23.2 0.5
C4 A:EAA210 2.9 24.6 0.5
CL1 A:EAA210 3.2 22.4 0.5
C7 A:EAA210 3.3 25.8 0.5
CD2 A:PHE8 3.6 17.7 1.0
CA A:GLY205 3.6 24.1 1.0
CG1 A:VAL10 3.7 18.2 1.0
C11 A:EAA210 3.7 28.2 0.5
O1 A:EAA210 3.7 27.8 0.5
CG A:PHE8 3.8 18.8 1.0
CB A:PHE8 3.8 16.2 1.0
C8 A:EAA210 3.9 28.3 0.5
N A:GLY205 4.1 22.8 1.0
OH A:TYR108 4.1 26.8 1.0
CG2 A:VAL10 4.2 19.0 1.0
C5 A:EAA210 4.2 23.4 0.5
C1 A:EAA210 4.2 23.7 0.5
CE2 A:PHE8 4.3 20.1 1.0
CB A:VAL10 4.6 17.9 1.0
C6 A:EAA210 4.7 24.1 0.5
CD1 A:PHE8 4.7 20.2 1.0
C A:GLY205 4.8 25.9 1.0

Chlorine binding site 3 out of 5 in 3n9j

Go back to Chlorine Binding Sites List in 3n9j
Chlorine binding site 3 out of 5 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl210

b:26.7
occ:0.20
 PT A:PT211 2.4 32.3 0.2
O A:HOH377 2.5 43.1 1.0
O B:HOH322 2.6 24.7 1.0
SG B:CYS101 3.1 19.7 0.4
CB B:CYS101 3.4 17.3 0.4
CB B:CYS101 3.4 15.8 0.6
SG B:CYS101 3.7 14.6 0.6
SG A:CYS101 3.8 21.6 0.3
O A:HOH369 3.9 40.3 1.0
OD1 B:ASP98 4.1 21.0 1.0
SG A:CYS101 4.3 21.2 0.7
O B:HOH376 4.3 44.3 1.0
O B:ASP98 4.6 13.1 1.0
O A:HOH367 4.6 40.7 1.0
CA B:ASP98 4.7 14.0 1.0
O B:HOH368 4.8 41.8 1.0
CA B:CYS101 4.9 17.3 0.4
CA B:CYS101 4.9 16.1 0.6
CG B:ASP98 4.9 17.1 1.0

Chlorine binding site 4 out of 5 in 3n9j

Go back to Chlorine Binding Sites List in 3n9j
Chlorine binding site 4 out of 5 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl214

b:30.4
occ:0.60
 CL1 B:EAA214 0.0 30.4 0.6
C2 B:EAA214 1.8 29.1 0.6
C3 B:EAA214 2.8 29.7 0.6
C1 B:EAA214 2.9 30.1 0.6
OH B:TYR7 2.9 18.5 1.0
CL2 B:EAA214 3.1 30.9 0.6
O2 B:EAA214 3.1 29.1 0.6
O B:HOH347 3.2 28.6 1.0
C12 B:EAA214 3.4 27.4 0.6
O B:EAA214 3.6 25.0 0.6
O B:HOH324 3.6 16.3 1.0
C13 B:EAA214 3.6 26.4 0.6
CZ B:TYR7 3.7 15.8 1.0
OH B:TYR108 3.8 19.8 1.0
CG2 B:VAL10 3.8 19.2 1.0
CD2 B:PHE8 4.0 22.1 1.0
C6 B:EAA214 4.1 30.4 0.6
C4 B:EAA214 4.1 30.4 0.6
CE1 B:TYR7 4.2 16.6 1.0
CE2 B:TYR7 4.4 16.7 1.0
CE2 B:PHE8 4.5 25.5 1.0
OXT B:EAA214 4.5 26.3 0.6
C5 B:EAA214 4.6 30.8 0.6
CZ B:TYR108 4.7 20.1 1.0
CA B:GLY12 4.9 14.2 1.0

Chlorine binding site 5 out of 5 in 3n9j

Go back to Chlorine Binding Sites List in 3n9j
Chlorine binding site 5 out of 5 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl214

b:30.9
occ:0.60
 CL2 B:EAA214 0.0 30.9 0.6
C3 B:EAA214 1.8 29.7 0.6
C2 B:EAA214 2.8 29.1 0.6
C4 B:EAA214 2.9 30.4 0.6
CL1 B:EAA214 3.1 30.4 0.6
C7 B:EAA214 3.2 30.8 0.6
O1 B:EAA214 3.3 30.3 0.6
CD2 B:PHE8 3.6 22.1 1.0
CA B:GLY205 3.6 21.8 1.0
CG B:PHE8 3.8 20.4 1.0
CB B:PHE8 3.9 20.4 1.0
CG1 B:VAL10 3.9 19.4 1.0
OH B:TYR108 4.0 19.8 1.0
CG2 B:VAL10 4.0 19.2 1.0
C11 B:EAA214 4.1 32.1 0.6
C8 B:EAA214 4.1 32.6 0.6
N B:GLY205 4.1 19.6 1.0
C5 B:EAA214 4.2 30.8 0.6
C1 B:EAA214 4.2 30.1 0.6
CE2 B:PHE8 4.3 25.5 1.0
CB B:VAL10 4.6 18.5 1.0
C6 B:EAA214 4.7 30.4 0.6
C B:GLY205 4.7 22.8 1.0
CD1 B:PHE8 4.7 23.2 1.0
CZ B:TYR108 4.9 20.1 1.0
O B:GLY205 5.0 24.3 1.0

Reference:

L.J.Parker, L.C.Italiano, C.J.Morton, N.C.Hancock, D.B.Ascher, J.B.Aitken, H.H.Harris, P.Campomanes, U.Rothlisberger, A.De Luca, M.Lo Bello, W.H.Ang, P.J.Dyson, M.W.Parker. Studies of Glutathione Transferase P1-1 Bound to A Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation. To Be Published.
Page generated: Sun Jul 21 00:45:19 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy