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Chlorine in PDB 3nza: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives

Enzymatic activity of Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives

All present enzymatic activity of Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives:
1.5.1.3;

Protein crystallography data

The structure of Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives, PDB code: 3nza was solved by V.Cody, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.89 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 36.959, 42.679, 60.609, 90.00, 94.57, 90.00
R / Rfree (%) 20.6 / 28.2

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives (pdb code 3nza). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives, PDB code: 3nza:

Chlorine binding site 1 out of 1 in 3nza

Go back to Chlorine Binding Sites List in 3nza
Chlorine binding site 1 out of 1 in the Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 5-(Omega-Carboxy(Alkyloxy) Pyrido[2,3-D]Pyrimidine Derivatives within 5.0Å range:
probe atom residue distance (Å) B Occ
X:Cl209

b:40.7
occ:1.00
 NH1 X:ARG75 3.1 30.3 1.0
NH2 X:ARG75 3.2 33.4 1.0
CB X:LYS37 3.6 25.3 1.0
CZ X:ARG75 3.6 28.5 1.0
CG X:LYS37 3.7 29.8 1.0
CAN X:D2K207 3.8 62.4 1.0
CD2 X:LEU72 3.8 36.3 1.0
CE2 X:PHE36 4.0 28.6 1.0
CA X:LYS37 4.1 26.3 1.0
CD2 X:PHE36 4.1 24.2 1.0
CD X:LYS37 4.2 35.9 1.0
CE X:LYS37 4.4 40.6 1.0
N X:LYS37 4.6 24.6 1.0
CAM X:D2K207 4.6 57.4 1.0
CAL X:D2K207 4.6 58.8 1.0
CG X:LEU72 4.8 36.1 1.0
NZ X:LYS37 4.8 46.5 1.0
CD1 X:LEU72 4.9 32.5 1.0
NE X:ARG75 4.9 27.9 1.0
CB X:LEU72 4.9 34.8 1.0
CAV X:D2K207 4.9 66.3 1.0

Reference:

V.Cody, J.Pace. Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and A Series of Five Potent 6-[5'-([Omega]-Carboxyalkoxy)Benzyl]Pyrido[2,3-D]Pyrimidine Derivatives Acta Crystallogr.,Sect.D V. 67 1 2011.
ISSN: ISSN 0907-4449
PubMed: 21206056
DOI: 10.1107/S0907444910041004
Page generated: Sat Dec 12 09:58:39 2020

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