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Atomistry » Chlorine » PDB 3o6j-3ohg » 3og7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3o6j-3ohg » 3og7 » |
Chlorine in PDB 3og7: B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032Enzymatic activity of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032
All present enzymatic activity of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032:
2.7.11.1; Protein crystallography data
The structure of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032, PDB code: 3og7
was solved by
Y.Zhang,
K.Y.Zhang,
C.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3og7:
The structure of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032
(pdb code 3og7). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032, PDB code: 3og7: Chlorine binding site 1 out of 1 in 3og7Go back to Chlorine Binding Sites List in 3og7
Chlorine binding site 1 out
of 1 in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX4032
Mono view Stereo pair view
Reference:
G.Bollag,
P.Hirth,
J.Tsai,
J.Zhang,
P.N.Ibrahim,
H.Cho,
W.Spevak,
C.Zhang,
Y.Zhang,
G.Habets,
E.A.Burton,
B.Wong,
G.Tsang,
B.L.West,
B.Powell,
R.Shellooe,
A.Marimuthu,
H.Nguyen,
K.Y.Zhang,
D.R.Artis,
J.Schlessinger,
F.Su,
B.Higgins,
R.Iyer,
K.D'andrea,
A.Koehler,
M.Stumm,
P.S.Lin,
R.J.Lee,
J.Grippo,
I.Puzanov,
K.B.Kim,
A.Ribas,
G.A.Mcarthur,
J.A.Sosman,
P.B.Chapman,
K.T.Flaherty,
X.Xu,
K.L.Nathanson,
K.Nolop.
Clinical Efficacy of A Raf Inhibitor Needs Broad Target Blockade in Braf-Mutant Melanoma. Nature V. 467 596 2010.
Page generated: Sat Dec 12 09:59:42 2020
ISSN: ISSN 0028-0836 PubMed: 20823850 DOI: 10.1038/NATURE09454 |
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