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Chlorine in PDB 3p10: Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol

Enzymatic activity of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol

All present enzymatic activity of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol:
4.6.1.12;

Protein crystallography data

The structure of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol, PDB code: 3p10 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.91 / 1.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 117.540, 67.550, 60.070, 90.00, 95.99, 90.00
R / Rfree (%) 15.9 / 19.2

Other elements in 3p10:

The structure of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol also contains other interesting chemical elements:

Potassium (K) 1 atom
Zinc (Zn) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol (pdb code 3p10). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol, PDB code: 3p10:

Chlorine binding site 1 out of 1 in 3p10

Go back to Chlorine Binding Sites List in 3p10
Chlorine binding site 1 out of 1 in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL694, 2- (Thiophen-2-Yl)Phenyl Methanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl163

b:25.8
occ:1.00
 O A:HOH221 3.0 30.9 1.0
N A:LYS138 3.1 17.0 1.0
N A:ASN136 3.3 13.1 1.0
CA A:GLY143 3.6 14.9 1.0
CG A:GLN103 3.6 14.3 1.0
CA A:LYS138 3.7 17.9 1.0
N A:GLU137 3.7 14.2 1.0
CB A:THR135 3.7 13.4 1.0
CB A:GLN103 3.8 13.5 1.0
C A:ASN136 3.9 14.0 1.0
CA A:GLN103 3.9 12.4 1.0
CA A:ASN136 4.0 13.0 1.0
OG1 A:THR135 4.2 14.3 1.0
C A:GLU137 4.2 17.0 1.0
O A:GLY143 4.2 15.0 1.0
C A:THR135 4.3 13.8 1.0
CB A:ASN136 4.3 12.2 1.0
CA A:THR135 4.3 13.4 1.0
CA A:GLU137 4.3 16.1 1.0
N A:GLY143 4.4 13.7 1.0
C A:GLY143 4.4 15.5 1.0
O A:LEU142 4.5 15.3 1.0
N A:GLN103 4.5 11.8 1.0
O A:ASN136 4.6 13.3 1.0
C A:LYS138 4.6 17.4 1.0
CG2 A:THR135 4.7 16.2 1.0
O A:HOH227 4.7 42.2 1.0
CG A:LYS138 4.7 21.8 1.0
C A:LEU142 4.8 12.9 1.0
CB A:LYS138 4.8 18.0 1.0
O A:HOH256 4.8 19.4 1.0
N A:LEU139 4.8 15.6 1.0

Reference:

D.W.Begley, R.C.Hartley, D.R.Davies, T.E.Edwards, J.T.Leonard, J.Abendroth, C.A.Burris, J.Bhandari, P.J.Myler, B.L.Staker, L.J.Stewart. Leveraging Structure Determination with Fragment Screening For Infectious Disease Drug Targets: Mecp Synthase From Burkholderia Pseudomallei. J Struct Funct Genomics V. 12 63 2011.
PubMed: 21359640
DOI: 10.1007/S10969-011-9102-6
Page generated: Sun Jul 21 02:06:47 2024

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