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Chlorine in PDB 3pmh: Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites

Enzymatic activity of Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites

All present enzymatic activity of Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites:
3.4.21.5;

Protein crystallography data

The structure of Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites, PDB code: 3pmh was solved by K.I.Varughese, R.Celikel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 3.20
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 67.657, 67.657, 329.730, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 26.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites (pdb code 3pmh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites, PDB code: 3pmh:

Chlorine binding site 1 out of 1 in 3pmh

Go back to Chlorine Binding Sites List in 3pmh
Chlorine binding site 1 out of 1 in the Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct Alpha-Thrombin Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl700

b:20.3
occ:1.00
 CL1 B:0G7700 0.0 20.3 1.0
C3 B:0G7700 1.8 31.7 1.0
N B:GLY193 2.4 39.6 1.0
C2 B:0G7700 2.8 38.8 1.0
C B:GLU192 3.3 43.6 1.0
CA B:GLY193 3.3 38.3 1.0
CA B:GLU192 3.4 45.1 1.0
O2 B:0G7700 3.6 41.6 1.0
CA2 B:0G7700 3.6 38.3 1.0
CB B:GLU192 3.6 54.7 1.0
C B:GLY193 4.3 38.4 1.0
O B:GLU192 4.5 41.1 1.0
OG B:SER195 4.5 33.5 1.0
N B:ASP194 4.5 33.0 1.0
O1 B:0G7700 4.5 44.6 1.0
CB2 B:0G7700 4.6 33.5 1.0
N2 B:0G7700 4.7 38.9 1.0
O B:LEU41 4.7 52.0 1.0
N B:GLU192 4.8 42.3 1.0
C1 B:0G7700 5.0 40.2 1.0

Reference:

A.Zarpellon, R.Celikel, J.R.Roberts, R.A.Mcclintock, G.L.Mendolicchio, K.L.Moore, H.Jing, K.I.Varughese, Z.M.Ruggeri. Binding of Alpha-Thrombin to Surface-Anchored Platelet Glycoprotein Ib(Alpha) Sulfotyrosines Through A Two-Site Mechanism Involving Exosite I. Proc.Natl.Acad.Sci.Usa V. 108 8628 2011.
ISSN: ISSN 0027-8424
PubMed: 21555542
DOI: 10.1073/PNAS.1017042108
Page generated: Sat Dec 12 10:02:50 2020

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