Chlorine in PDB 3pp4: Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies

The structure of Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies, PDB code: 3pp4 was solved by K.-P.Hopfner, A.Lammens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.95 / 1.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	84.050, 85.900, 72.870, 90.00, 116.34, 90.00
R / Rfree (%)	13.7 / 18.7

The binding sites of Chlorine atom in the Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies (pdb code 3pp4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies, PDB code: 3pp4:

Chlorine binding site 1 out of 1 in the Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For the Type I / Type II Distinction of Anti- CD20 Antibodies within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl225 b:12.2 occ:0.98 OH L:TYR101 3.1 12.8 1.0 NH1 H:ARG50 3.2 12.8 1.0 ND2 H:ASN35 3.3 9.1 1.0 CB H:ASN99 3.5 10.9 1.0 CG H:ASN99 3.5 10.9 1.0 CE2 L:TYR101 3.6 11.2 1.0 OD1 H:ASN35 3.7 13.7 1.0 CB P:SER173 3.8 11.5 1.0 CZ L:TYR101 3.8 11.7 1.0 ND2 H:ASN99 3.8 11.9 1.0 CD H:ARG50 3.9 11.6 1.0 NE1 H:TRP105 3.9 12.7 1.0 CA P:SER173 3.9 12.7 1.0 CB H:TRP33 3.9 11.0 1.0 OD1 H:ASN99 3.9 13.7 1.0 CG H:ASN35 3.9 10.1 1.0 CD1 H:TRP105 4.1 12.1 1.0 CG H:TRP33 4.2 11.6 1.0 CZ H:ARG50 4.3 13.2 1.0 CD1 H:TRP33 4.5 12.0 1.0 NE H:ARG50 4.5 12.7 1.0 N P:SER173 4.8 14.2 1.0 CD2 L:TYR101 4.9 10.7 1.0 C P:SER173 4.9 12.1 1.0 CA H:ASN99 4.9 10.9 1.0 O P:SER173 4.9 13.9 1.0 O P:PRO172 4.9 12.4 1.0 CD2 H:TRP33 5.0 12.0 1.0

G.Niederfellner, A.Lammens, O.Mundigl, G.J.Georges, W.Schaefer, M.Schwaiger, A.Franke, K.Wiechmann, S.Jenewein, J.W.Slootstra, P.Timmerman, A.Brannstrom, F.Lindstrom, E.Mossner, P.Umana, K.P.Hopfner, C.Klein. Epitope Characterization and Crystal Structure of GA101 Provide Insights Into the Molecular Basis For Type I/II Distinction of CD20 Antibodies. Blood V. 118 358 2011.
ISSN: ISSN 0006-4971
PubMed: 21444918
DOI: 10.1182/BLOOD-2010-09-305847