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Atomistry » Chlorine » PDB 3q18-3qck » 3q2z | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3q18-3qck » 3q2z » |
Chlorine in PDB 3q2z: Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic AcidEnzymatic activity of Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid
All present enzymatic activity of Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid:
2.5.1.21; Protein crystallography data
The structure of Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid, PDB code: 3q2z
was solved by
M.Suzuki,
H.Shimizu,
S.Katakura,
K.Yamazaki,
N.Higashihashi,
M.Ichikawa,
A.Yokomizo,
M.Itoh,
K.Sugita,
H.Usui,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid
(pdb code 3q2z). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid, PDB code: 3q2z: Chlorine binding site 1 out of 1 in 3q2zGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Human Squalene Synthase in Complex with N-[(3R,5S)-7-Chloro-5-(2,3- Dimethoxyphenyl)-1-Neopentyl-2-Oxo-1,2,3,5-Tetrahydro-4,1- Benzoxazepine-3-Acetyl]-L-Aspartic Acid
![]() Mono view ![]() Stereo pair view
Reference:
M.Ichikawa,
A.Yokomizo,
M.Itoh,
K.Sugita,
H.Usui,
H.Shimizu,
M.Suzuki,
K.Terayama,
A.Kanda.
Discovery of A New 2-Aminobenzhydrol Template For Highly Potent Squalene Synthase Inhibitors Bioorg.Med.Chem. V. 19 1930 2011.
Page generated: Fri Jul 11 09:17:25 2025
ISSN: ISSN 0968-0896 PubMed: 21353782 DOI: 10.1016/J.BMC.2011.01.065 |
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