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Chlorine in PDB 3rbf: Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form

Enzymatic activity of Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form

All present enzymatic activity of Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form:
4.1.1.28;

Protein crystallography data

The structure of Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form, PDB code: 3rbf was solved by G.Giardina, R.Montioli, S.Gianni, B.Cellini, A.Paiardini, C.Borrivoltattorni, F.Cutruzzola, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.77 / 2.90
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 175.840, 175.840, 74.960, 90.00, 90.00, 90.00
R / Rfree (%) 21.2 / 26.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form (pdb code 3rbf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form, PDB code: 3rbf:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 3rbf

Go back to Chlorine Binding Sites List in 3rbf
Chlorine binding site 1 out of 2 in the Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl481

b:33.4
occ:1.00
NE1 B:TRP304 3.3 29.6 1.0
NZ B:LYS303 3.5 28.5 1.0
N B:ALA275 3.7 24.5 1.0
CB B:TYR274 3.9 28.4 1.0
CE B:LYS303 3.9 28.7 1.0
CD1 B:LEU406 4.0 24.2 1.0
CA B:ALA275 4.0 24.0 1.0
CD B:LYS303 4.1 29.2 1.0
C B:TYR274 4.2 25.3 1.0
SG B:CYS249 4.2 30.6 1.0
CB B:ALA275 4.2 23.7 1.0
CE2 B:TRP304 4.3 31.2 1.0
CD1 B:TRP304 4.3 27.5 1.0
CZ2 B:TRP304 4.5 33.9 1.0
CA B:TYR274 4.5 27.0 1.0
CD2 B:TYR274 4.7 34.4 1.0
O B:TYR274 4.8 25.2 1.0
CG B:TYR274 4.8 31.4 1.0
N B:TYR274 4.9 26.6 1.0

Chlorine binding site 2 out of 2 in 3rbf

Go back to Chlorine Binding Sites List in 3rbf
Chlorine binding site 2 out of 2 in the Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Aromatic L-Amino Acid Decarboxylase (Aadc) in the Apo Form within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl482

b:45.9
occ:1.00
CG B:PRO282 3.3 28.4 1.0
NH1 B:ARG285 3.5 45.3 1.0
CD B:PRO282 3.9 27.5 1.0
NH2 B:ARG285 3.9 45.7 1.0
CZ B:ARG285 4.1 42.9 1.0
NE2 B:GLN375 4.2 24.4 1.0
CB B:PRO282 4.6 28.2 1.0
O B:ILE280 4.9 27.6 1.0

Reference:

G.Giardina, R.Montioli, S.Gianni, B.Cellini, A.Paiardini, C.B.Voltattorni, F.Cutruzzola. Open Conformation of Human Dopa Decarboxylase Reveals the Mechanism of Plp Addition to Group II Decarboxylases. Proc.Natl.Acad.Sci.Usa V. 108 20514 2011.
ISSN: ISSN 0027-8424
PubMed: 22143761
DOI: 10.1073/PNAS.1111456108
Page generated: Sat Dec 12 10:06:42 2020

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