Chlorine in PDB 3s8w: D2 Domain of Human IFNAR2

The structure of D2 Domain of Human IFNAR2, PDB code: 3s8w was solved by C.Thomas, K.C.Garcia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.93 / 2.60
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	82.660, 82.660, 225.330, 90.00, 90.00, 120.00
R / Rfree (%)	21.8 / 27

The binding sites of Chlorine atom in the D2 Domain of Human IFNAR2 (pdb code 3s8w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the D2 Domain of Human IFNAR2, PDB code: 3s8w:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the D2 Domain of Human IFNAR2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of D2 Domain of Human IFNAR2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1 b:79.6 occ:1.00 NZ A:LYS172 2.7 58.2 1.0 N C:ASN161 3.7 53.9 1.0 CA C:GLY160 4.1 50.1 1.0 CE A:LYS172 4.1 56.9 1.0 O C:ASN161 4.4 55.9 1.0 C C:GLY160 4.4 51.4 1.0 O C:LYS159 4.4 60.4 1.0 CA C:ASN161 4.6 58.8 1.0 CB C:ASN161 4.7 66.7 1.0 NZ C:LYS159 4.8 78.2 1.0 ND2 C:ASN161 4.8 77.1 1.0 CD A:LYS172 4.9 54.6 1.0 C C:ASN161 4.9 56.0 1.0 N C:GLY160 4.9 52.8 1.0

Chlorine binding site 2 out of 2 in the D2 Domain of Human IFNAR2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of D2 Domain of Human IFNAR2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1 b:63.0 occ:1.00 N A:THR167 3.6 36.9 1.0 O C:LYS155 3.7 45.4 1.0 C C:LYS155 3.7 37.2 1.0 N C:LYS155 3.9 42.5 1.0 N C:PRO156 3.9 30.7 1.0 OH C:TYR168 4.0 59.5 1.0 CA C:PRO156 4.1 37.7 1.0 O C:HOH13 4.2 45.1 1.0 CB A:THR167 4.2 32.4 1.0 OG1 A:THR167 4.3 37.4 1.0 CA A:PHE166 4.3 48.5 1.0 C A:PHE166 4.4 44.4 1.0 CA C:LYS155 4.4 41.2 1.0 CA A:THR167 4.5 31.3 1.0 CD C:PRO156 4.7 31.2 1.0 CB C:PRO156 4.7 37.0 1.0 C C:HIS154 4.7 45.9 1.0 O A:ASN165 4.7 77.5 1.0 O A:THR167 4.8 28.0 1.0 CZ C:TYR168 4.9 53.4 1.0 CA C:HIS154 4.9 45.6 1.0 CE1 C:TYR168 5.0 51.6 1.0 CB A:PHE166 5.0 43.0 1.0

C.Thomas, I.Moraga, D.Levin, P.O.Krutzik, Y.Podoplelova, A.Trejo, C.Lee, G.Yarden, S.E.Vleck, J.S.Glenn, G.P.Nolan, J.Piehler, G.Schreiber, K.C.Garcia. Structural Linkage Between Ligand Discrimination and Receptor Activation By Type I Interferons. Cell(Cambridge,Mass.) V. 146 621 2011.
ISSN: ISSN 0092-8674
PubMed: 21854986
DOI: 10.1016/J.CELL.2011.06.048