Chlorine in PDB 3s9o: The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

Enzymatic activity of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

All present enzymatic activity of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis:
2.7.10.2;

Protein crystallography data

The structure of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis, PDB code: 3s9o was solved by S.T.Arold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.43 / 2.60
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	89.918, 223.983, 98.015, 90.00, 90.00, 90.00
*R / R_free (%)*	23.3 / 28.7

Other elements in 3s9o:

The structure of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis (pdb code 3s9o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis, PDB code: 3s9o:

Chlorine binding site 1 out of 1 in 3s9o

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Chlorine Binding Sites List in 3s9o

Chlorine binding site 1 out of 1 in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl36 b:69.7 occ:1.00	O	B:HOH27	2.9	31.4	1.0
	NH2	A:ARG1042	3.3	64.4	1.0
	N	A:LYS923	3.4	57.7	1.0
	CB	A:LYS923	3.5	57.8	1.0
	CA	A:LYS923	4.0	56.6	1.0
	N	A:VAL924	4.1	52.8	1.0
	O	A:ASN921	4.1	65.1	1.0
	OD1	A:ASP922	4.3	60.6	1.0
	CA	A:ASP922	4.3	60.5	1.0
	C	A:ASP922	4.3	58.9	1.0
	OG1	A:THR971	4.4	60.4	1.0
	CG2	A:VAL924	4.4	49.9	1.0
	CZ	A:ARG1042	4.6	64.0	1.0
	C	A:LYS923	4.6	54.6	1.0
	CG	A:LYS923	4.6	62.3	1.0
	CG	A:ASP922	4.8	60.1	1.0

Reference:

G.Kadare, N.Gervasi, K.Brami-Cherrier, H.Blockus, S.El Messari, S.T.Arold, J.A.Girault. Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells. J.Biol.Chem. V. 290 478 2015.
ISSN: ISSN 0021-9258
PubMed: 25391654
DOI: 10.1074/JBC.M114.593632

Page generated: Sun Jul 21 04:15:45 2024

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