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Chlorine in PDB 3thb: Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
Enzymatic activity of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
All present enzymatic activity of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor:
2.7.11.21;
2.7.11.21;
Protein crystallography data
The structure of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor, PDB code: 3thb
was solved by
M.D.Sintchak,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.50 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.668, 67.668, 154.684, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 25 / 28.6 |
Other elements in 3thb:
The structure of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
(pdb code 3thb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor, PDB code: 3thb:
In total only one binding site of Chlorine was determined in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor, PDB code: 3thb:
Chlorine binding site 1 out of 1 in 3thb
Go back to
Chlorine Binding Sites List in 3thb
Chlorine binding site 1 out
of 1 in the Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Structure of PLK1 Kinase Domain in Complex with A Benzolactam-Derived Inhibitor within 5.0Å range:
|
Reference:
M.O.Duffey,
T.J.Vos,
R.Adams,
J.Alley,
J.Anthony,
C.Barrett,
I.Bharathan,
D.Bowman,
N.J.Bump,
R.Chau,
C.Cullis,
D.L.Driscoll,
A.Elder,
N.Forsyth,
J.Frazer,
J.Guo,
L.Guo,
M.L.Hyer,
D.Janowick,
B.Kulkarni,
S.J.Lai,
K.Lasky,
G.Li,
J.Li,
D.Liao,
J.Little,
B.Peng,
M.G.Qian,
D.J.Reynolds,
M.Rezaei,
M.P.Scott,
T.B.Sells,
V.Shinde,
Q.J.Shi,
M.D.Sintchak,
F.Soucy,
K.T.Sprott,
S.G.Stroud,
M.Nestor,
I.Visiers,
G.Weatherhead,
Y.Ye,
N.D'amore.
Discovery of A Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J.Med.Chem. V. 55 197 2012.
ISSN: ISSN 0022-2623
PubMed: 22070629
DOI: 10.1021/JM2011172
Page generated: Sun Jul 21 05:12:41 2024
ISSN: ISSN 0022-2623
PubMed: 22070629
DOI: 10.1021/JM2011172
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