Chlorine in PDB 3tlt: The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)

The structure of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype), PDB code: 3tlt was solved by L.Sauguet, H.Nury, P.J.Corringer, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.04 / 3.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	180.370, 129.020, 160.530, 90.00, 102.14, 90.00
R / Rfree (%)	22.4 / 24.3

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) (pdb code 3tlt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype), PDB code: 3tlt:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl318 b:98.0 occ:1.00 N A:ARG85 3.4 0.7 1.0 NH1 A:ARG85 3.4 0.8 1.0 N A:PHE78 3.6 92.8 1.0 CD2 A:PHE78 3.6 99.6 1.0 CG A:ARG85 3.6 0.5 1.0 CA A:ALA84 3.8 0.6 1.0 CB A:ARG85 4.0 0.9 1.0 CA A:ARG77 4.1 95.5 1.0 C A:ALA84 4.1 0.8 1.0 CD A:ARG85 4.2 0.5 1.0 CB A:ALA84 4.2 0.3 1.0 CG2 A:VAL81 4.2 0.9 1.0 C A:ARG77 4.3 97.6 1.0 CB A:PHE78 4.3 94.5 1.0 CA A:ARG85 4.3 0.7 1.0 CZ A:ARG85 4.4 0.6 1.0 CG A:PHE78 4.4 96.4 1.0 CB A:ARG77 4.5 93.2 1.0 CA A:PHE78 4.5 92.6 1.0 CE2 A:PHE78 4.5 0.6 1.0 O A:PHE78 4.7 97.0 1.0 NE A:ARG85 4.7 0.3 1.0 N A:ALA84 5.0 0.8 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl319 b:0.1 occ:1.00 N B:ARG85 3.4 0.1 1.0 CD2 B:PHE78 3.4 96.5 1.0 NH1 B:ARG85 3.4 0.7 1.0 N B:PHE78 3.5 92.0 1.0 CG B:ARG85 3.6 0.1 1.0 CA B:ALA84 3.9 0.7 1.0 CB B:ARG85 3.9 0.9 1.0 CG2 B:VAL81 4.0 0.6 1.0 CB B:PHE78 4.1 92.4 1.0 CD B:ARG85 4.1 0.6 1.0 CA B:ARG77 4.1 96.9 1.0 C B:ALA84 4.1 0.6 1.0 CG B:PHE78 4.2 94.5 1.0 C B:ARG77 4.2 97.1 1.0 CA B:ARG85 4.3 0.6 1.0 CE2 B:PHE78 4.3 99.4 1.0 CA B:PHE78 4.3 90.9 1.0 CB B:ALA84 4.4 0.7 1.0 CZ B:ARG85 4.4 0.2 1.0 O B:PHE78 4.5 95.9 1.0 CB B:ARG77 4.6 96.2 1.0 NE B:ARG85 4.7 0.8 1.0 C B:PHE78 5.0 94.4 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl318 b:99.2 occ:1.00 N C:PHE78 3.3 82.5 1.0 N C:ARG85 3.6 90.9 1.0 CG2 C:VAL81 3.6 95.2 1.0 CD2 C:PHE78 3.6 85.9 1.0 CA C:ALA84 3.7 92.6 1.0 CB C:PHE78 3.9 82.4 1.0 NH1 C:ARG85 3.9 67.9 1.0 O C:PHE78 4.1 87.5 1.0 CA C:PHE78 4.1 81.2 1.0 CA C:ARG77 4.1 86.6 1.0 C C:ARG77 4.1 89.4 1.0 CG C:ARG85 4.2 85.7 1.0 C C:ALA84 4.2 97.5 1.0 CB C:ALA84 4.2 93.4 1.0 CG C:PHE78 4.2 83.3 1.0 CB C:ARG85 4.4 87.8 1.0 CB C:ARG77 4.4 84.1 1.0 C C:PHE78 4.6 85.9 1.0 CA C:ARG85 4.6 90.2 1.0 CD C:ARG85 4.6 86.8 1.0 CE2 C:PHE78 4.6 87.6 1.0 CB C:VAL81 4.7 95.3 1.0 O C:ASN83 4.8 95.3 1.0 N C:ALA84 4.8 92.2 1.0 CG1 C:VAL81 4.8 95.0 1.0 CZ C:ARG85 5.0 90.3 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl318 b:0.3 occ:1.00 N D:PHE78 3.4 96.3 1.0 N D:ARG85 3.5 0.3 1.0 NH1 D:ARG85 3.6 0.5 1.0 CD2 D:PHE78 3.7 0.4 1.0 CA D:ALA84 3.7 0.7 1.0 CG D:ARG85 3.9 0.2 1.0 CA D:ARG77 4.0 96.9 1.0 CG2 D:VAL81 4.0 0.7 1.0 C D:ARG77 4.1 0.9 1.0 CB D:ALA84 4.1 0.6 1.0 C D:ALA84 4.2 0.2 1.0 CB D:PHE78 4.2 98.1 1.0 CB D:ARG85 4.3 0.8 1.0 CB D:ARG77 4.3 95.6 1.0 CA D:PHE78 4.3 96.0 1.0 O D:PHE78 4.4 98.9 1.0 CG D:PHE78 4.4 0.3 1.0 CD D:ARG85 4.4 0.6 1.0 CA D:ARG85 4.5 0.6 1.0 CE2 D:PHE78 4.7 0.1 1.0 CZ D:ARG85 4.7 0.8 1.0 C D:PHE78 4.8 98.7 1.0 N D:ALA84 4.9 0.7 1.0 CG D:ARG77 4.9 0.9 1.0 NE D:ARG85 5.0 0.3 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel H11'F Mutant in A Locally-Closed Conformation (LC1 Subtype) within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl318 b:99.3 occ:1.00 N E:ARG85 2.9 96.5 1.0 CG E:ARG85 3.4 95.9 1.0 CA E:ALA84 3.5 98.7 1.0 CD2 E:PHE78 3.6 90.1 1.0 CB E:ARG85 3.6 94.4 1.0 NH1 E:ARG85 3.6 94.2 1.0 C E:ALA84 3.7 0.2 1.0 CA E:ARG85 3.9 96.0 1.0 N E:PHE78 3.9 92.1 1.0 CB E:ALA84 4.0 99.4 1.0 CD E:ARG85 4.0 0.0 1.0 CG2 E:VAL81 4.1 0.9 1.0 CB E:PHE78 4.4 89.3 1.0 CE2 E:PHE78 4.4 92.1 1.0 CG E:PHE78 4.5 88.7 1.0 CA E:ARG77 4.5 0.8 1.0 CZ E:ARG85 4.5 0.3 1.0 NE E:ARG85 4.7 97.6 1.0 O E:ASN83 4.7 0.4 1.0 C E:ARG77 4.7 99.9 1.0 N E:ALA84 4.7 99.3 1.0 CA E:PHE78 4.7 89.6 1.0 O E:PHE78 4.9 98.2 1.0 O E:ALA84 4.9 0.8 1.0 CB E:ARG77 4.9 0.5 1.0 C E:ARG85 5.0 0.7 1.0

M.S.Prevost, L.Sauguet, H.Nury, C.Van Renterghem, C.Huon, F.Poitevin, M.Baaden, M.Delarue, P.J.Corringer. A Locally Closed Conformation of A Bacterial Pentameric Proton-Gated Ion Channel. Nat.Struct.Mol.Biol. V. 19 642 2012.
ISSN: ISSN 1545-9993
PubMed: 22580559
DOI: 10.1038/NSMB.2307