Chlorine in PDB 3tnm: Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody

The structure of Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody, PDB code: 3tnm was solved by X.Wu, M.Pazgier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.85
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	40.780, 71.316, 77.673, 103.69, 104.02, 105.40
R / Rfree (%)	18.7 / 23.2

The binding sites of Chlorine atom in the Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody (pdb code 3tnm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody, PDB code: 3tnm:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl213 b:64.7 occ:1.00 CA L:SER152 3.4 57.8 1.0 CB L:SER152 3.6 66.0 1.0 NE2 L:GLN194 3.7 56.9 1.0 CG L:LYS149 4.0 39.8 1.0 O L:SER152 4.1 60.5 1.0 C L:SER152 4.2 55.6 1.0 N L:SER152 4.2 50.8 1.0 CB L:LYS149 4.5 37.7 1.0 OE1 L:GLU203 4.7 69.6 1.0 CD L:LYS149 5.0 43.0 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl214 b:64.8 occ:1.00 N L:SER18 3.7 36.2 1.0 CD B:ARG189 4.0 65.0 1.0 O L:SER18 4.0 41.1 1.0 CB L:GLN17 4.0 34.1 1.0 CA L:GLN17 4.3 35.0 1.0 CG B:ARG189 4.3 50.9 1.0 CG L:GLN17 4.3 39.6 1.0 OG L:SER18 4.4 47.0 1.0 OG B:SER190 4.5 23.0 1.0 C L:GLN17 4.5 36.7 1.0 CA L:SER18 4.6 38.3 1.0 C L:SER18 4.8 37.7 1.0 CB L:SER18 4.8 38.6 1.0 CD L:GLN17 4.9 44.5 1.0 CB B:SER190 5.0 23.6 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of A32 Fab, An Adcc Mediating Anti-Hiv-1 Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl222 b:50.5 occ:1.00 N A:GLY10 2.8 21.7 1.0 OG1 A:THR107 2.9 30.4 1.0 C A:GLY8 3.2 23.3 1.0 O A:MET108 3.2 19.4 1.0 CA A:GLY8 3.3 22.7 1.0 N A:PRO9 3.3 23.5 1.0 CA A:GLY10 3.4 22.1 1.0 CD A:PRO9 3.6 21.4 1.0 O A:HOH309 3.6 44.3 1.0 O A:GLY8 3.7 21.9 1.0 CG2 A:VAL109 3.8 18.3 1.0 C A:PRO9 3.9 23.3 1.0 N A:GLY8 4.0 20.3 1.0 CB A:THR107 4.0 27.8 1.0 CG2 A:THR107 4.1 28.3 1.0 CA A:PRO9 4.2 24.0 1.0 C A:MET108 4.2 17.9 1.0 CG A:PRO9 4.4 24.6 1.0 C A:GLY10 4.4 21.8 1.0 CD2 A:LEU20 4.6 28.0 1.0 N A:MET108 4.7 22.6 1.0 CA A:VAL109 4.8 16.8 1.0 O A:GLY10 4.8 22.1 1.0 C A:THR107 4.8 24.1 1.0 CB A:VAL109 4.9 17.1 1.0 N A:VAL109 4.9 19.0 1.0 O A:PRO9 5.0 22.7 1.0 CA A:THR107 5.0 26.4 1.0

Y.Guan, M.Pazgier, M.M.Sajadi, R.Kamin-Lewis, S.Al-Darmarki, R.Flinko, E.Lovo, X.Wu, J.E.Robinson, M.S.Seaman, T.R.Fouts, R.C.Gallo, A.L.Devico, G.K.Lewis. Diverse Specificity and Effector Function Among Human Antibodies to Hiv-1 Envelope Glycoprotein Epitopes Exposed By CD4 Binding. Proc.Natl.Acad.Sci.Usa V. 110 E69 2013.
ISSN: ISSN 0027-8424
PubMed: 23237851
DOI: 10.1073/PNAS.1217609110